{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:14:02Z","timestamp":1761513242778},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>Primary cutaneous marginal zone lymphoma (<jats:styled-content style=\"fixed-case\">PCMZL<\/jats:styled-content>) has rarely been reported in teenagers and is occasionally associated with <jats:italic>Borrelia burgdorferi<\/jats:italic> infection. Juxta\u2010articular fibrotic nodules represent a unique, localized fibrosing response to spirochete infections, namely Borreliosis. Herein, we report a 15\u2010year\u2010old healthy boy who presented with a 4\u2010year history of progressive acquisition of asymptomatic, erythematous nodules, \u22643\u2009cm, beginning with his right forearm (3), then right arm (1) and lastly his right inner thigh (1). Biopsy showed <jats:styled-content style=\"fixed-case\">PCMZL<\/jats:styled-content> in three of five samples, and inflamed, fibrotic nodules, near the elbow in two. The bottom heavy lymphomatous nodules consisted of mostly small <jats:styled-content style=\"fixed-case\">CD20<\/jats:styled-content>+ <jats:styled-content style=\"fixed-case\">CD43<\/jats:styled-content>+ lymphocytes, some with plasmacytoid features. Mature plasma cells were lambda light chain restricted by <jats:italic>in situ<\/jats:italic> hybridization. The juxta\u2010articular fibrotic nodules were located in the deep dermis and subcutis, had peripheral plasma cell\u2010rich infiltrates, and showed nodular sclerosis (morphea profunda\u2010like) in one, and lamellar and angiocentric sclerosis in the other reminiscent of quiescent lesions of chronic localized fibrosing leukocytoclastic vasculitis. Immunohistochemistry for <jats:italic>B. burgdorferi<\/jats:italic> revealed rare positive organisms; however, polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>) and serology were negative for <jats:italic>B. burgdorferi<\/jats:italic> as were serologic and\/or <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> assays for <jats:italic>Bartonella henselae<\/jats:italic>, <jats:italic>Ba. quintana<\/jats:italic>, <jats:italic>Ehrlichia chaffeensis, Treponema pallidum, Helicobacter pylori<\/jats:italic> and <jats:italic>Babesia microti<\/jats:italic>. No evidence of extracutaneous disease was found by the review of systems and imaging studies. A 4\u2010week trial of doxycycline therapy failed, whereas intralesional (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>) corticosteroid therapy induced rapid regression of his nodules. After two local recurrences, also treated with <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content> corticosteroids, he is well, without cutaneous disease, 20\u2009months later. A literature review of 19 pediatric cases <jats:styled-content style=\"fixed-case\">PCMZL<\/jats:styled-content> reveals a similar natural history as adult <jats:styled-content style=\"fixed-case\">PCMZL<\/jats:styled-content>. Despite negative serology and <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> for <jats:italic>B. burgdorferi<\/jats:italic>, the occurrence of ipsilateral juxta\u2010articular fibrotic nodules, positive <jats:italic>B. burgdorferi<\/jats:italic> immunohistochemistry and rapid response to <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content> corticosteroids implicate the presence of a replicative or non\u2010replicative infectious (spirochetal) antigen in the initiation and promotion of this teenager's <jats:styled-content style=\"fixed-case\">PCMZL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cup.12102","type":"journal-article","created":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T22:32:43Z","timestamp":1359671563000},"page":"477-484","source":"Crossref","is-referenced-by-count":12,"title":["Primary cutaneous marginal zone lymphoma associated with juxta\u2010articular fibrotic nodules in a teenager"],"prefix":"10.1111","volume":"40","author":[{"given":"Pooja","family":"Ghatalia","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Albany Medical College  Albany NY 12208 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Albany Medical College  Albany NY 12208 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Wroblewski","sequence":"additional","affiliation":[{"name":"Wadsworth Center New York State Department Health  Albany NY 12208 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Andrew","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Pathology Albany Medical College  Albany NY 12208 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2011.07852_suppl.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1997.tb01318.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200009000-00012"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.281002.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200308000-00003"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10902.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1943.01510060050008"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00503626"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00264.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01513-1"},{"key":"e_1_2_5_12_1","first-page":"135","article-title":"Histopathology and immunohistochemistry of dermatoborreliosis","volume":"10","author":"Weger W","year":"2001","journal-title":"Acta Dermatovenerol Alp Panonica Adriat"},{"key":"e_1_2_5_13_1","first-page":"34","article-title":"Hautbefunde bei Lyme\u2010Borreliose. 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