{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:28:17Z","timestamp":1778498897835,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:00:00Z","timestamp":1363219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Background<\/jats:title>Until the 1990s, basal cell carcinoma (BCC<\/jats:styled-content>) was viewed as the most common epithelial neoplasm developing in association with nevus sebaceus (NS<\/jats:styled-content>). Currently, trichoblastoma is thought of as the most prevalent basaloid neoplasm in NS<\/jats:styled-content>. The follicular stem cell marker pleckstrin homology\u2010like domain, family A, member 1 (PHLDA1<\/jats:styled-content>) also known as T\u2010cell death\u2010associated gene 51 (TDAG51<\/jats:styled-content>) labels trichoepithelioma (TE) but not BCC<\/jats:styled-content>. Therefore, we explored its usefulness in basaloid neoplasms developing in NS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We studied immunohistochemically PHLDA1<\/jats:styled-content> in 10 nodular BCC<\/jats:styled-content>s, 11 TEs, 11 trichoblastomas and 25 NS<\/jats:styled-content> with basaloid tumors. Additionally, we examined the expression of BCC<\/jats:styled-content> marker BerEP4<\/jats:styled-content> and the distribution of Merkel cells that function as surrogate markers for benign follicular neoplasms.<\/jats:p><\/jats:sec>Results<\/jats:title>Nineteen of the 25 basaloid tumors in NS<\/jats:styled-content> were PHLDA1<\/jats:styled-content>\u2010negative comparable to BCC<\/jats:styled-content> arising de novo<\/jats:italic> and six tumors were PHLDA1<\/jats:styled-content>\u2010positive comparable to solitary trichoblastomas and TEs. Fewer Merkel cells were seen in BCCs<\/jats:styled-content> associated with NS<\/jats:styled-content> when compared with trichoblastoma. BerEP4<\/jats:styled-content> did not discriminate between the neoplasms.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We raise concern that the unquestioned assessment that basaloid tumors developing in association with NS<\/jats:styled-content> represent mostly trichoblastomas and not BCC<\/jats:styled-content> may not be true. This influences clinical care, as it is paramount in the decision of whether to excise these lesions or not.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12107","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T02:48:26Z","timestamp":1363315706000},"page":"455-462","source":"Crossref","is-referenced-by-count":26,"title":["Basaloid tumors in nevus sebaceus revisited: the follicular stem cell marker PHLDA1<\/scp> (TDAG51<\/scp>) indicates that most are basal cell carcinomas and not trichoblastomas"],"prefix":"10.1111","volume":"40","author":[{"given":"Klaus","family":"Sellheyer","sequence":"first","affiliation":[{"name":"Department of Dermatology Cleveland Clinic Foundation Cleveland OH USA"},{"name":"Nelson Dermatopathology Associates Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Cribier","sequence":"additional","affiliation":[{"name":"Clinique Dermatologique H\u00f4pitaux Universitaires de 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