{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:15:49Z","timestamp":1766268949703},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:00:00Z","timestamp":1363305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Peripheral T\u2010cell lymphoma (PTCL<\/jats:styled-content>), not otherwise specified (NOS<\/jats:styled-content>), represents a heterogeneous group of nodal and extranodal lymphomas that express a variety of T\u2010cell antigens indicative of mature T\u2010cell lineage. Most cases of PTCL<\/jats:styled-content> express CD4<\/jats:styled-content> and lack CD8<\/jats:styled-content> expression and have a T\u2010helper immunophenotype. Although the immunophenotype of PTCL<\/jats:styled-content> is usually stable over time, immunophenotypic switch or evolution from T\u2010helper to T\u2010suppressor or vice versa has been rarely reported. Herein, we report a patient who presented with nasal PTCL<\/jats:styled-content>, NOS<\/jats:styled-content>, that was CD8<\/jats:styled-content>+ and negative for Epstein\u2013Barr virus, with concurrent skin lesions that had a CD8<\/jats:styled-content>+\/TIA<\/jats:styled-content>\u20101+ T\u2010cell immunophenotype. Patient received multi\u2010agent chemotherapy and matched unrelated donor stem cell transplant, and subsequently suffered a cutaneous relapse with a CD4<\/jats:styled-content>+\/TIA<\/jats:styled-content>\u20101(\u2212) immunophenotype. Molecular analysis of the neoplasm biopsied at presentation showed one monoclonal T\u2010cell receptor gamma gene rearrangement, and a second oligoclonal peak. At the time of CD4<\/jats:styled-content>\u2010positive recurrence, the oligoclonal peak was rather prominent, suggesting that the emergence of this peak is related with the phenotypic evolution from CD8<\/jats:styled-content>+ to CD4<\/jats:styled-content>+ predominant. These results highlight the utility of sequential immunophenotypic and molecular analysis of PTCL<\/jats:styled-content> cases at the time of relapse to better understand the mechanisms of disease.<\/jats:p>","DOI":"10.1111\/cup.12112","type":"journal-article","created":{"date-parts":[[2013,2,21]],"date-time":"2013-02-21T23:11:15Z","timestamp":1361488275000},"page":"573-579","source":"Crossref","is-referenced-by-count":8,"title":["Phenotypic evolution in a case of peripheral T\u2010cell lymphoma suggests the presence of tumor heterogeneity"],"prefix":"10.1111","volume":"40","author":[{"given":"Alyaa","family":"Al\u2010Ibraheemi","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine The University of Texas Medical School at Houston Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":"Kanagal\u2010Shamanna","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas, M. D. Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyur P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas, M. D. Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergej N.","family":"Konoplev","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas, M. D. Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramod","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas, M. D. Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas, M. D. Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto N.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas, M. D. Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,15]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"9\u20102","volume-title":"Diagnostic pathology: lymph nodes and spleen with extranodal sites","author":"You MJ","year":"2011"},{"key":"e_1_2_5_3_1","first-page":"306","volume-title":"WHO classification of tumours of the haematopoietic and lymphoid tissues","author":"Pileri SA","year":"2008"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1306"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200001000-00014"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.6327"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-310342"},{"key":"e_1_2_5_8_1","first-page":"438","article-title":"Recurrences in nodal T\u2010cell lymphoma. 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