{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:19:33Z","timestamp":1778498373077,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:00:00Z","timestamp":1363219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>Herein, we report a 63\u2010year\u2010old man presenting with hidradenocarcinoma showing prominent mucinous and squamous differentiation on his back. The tumor was dermal\u2010based, solid and cystic. Tumor cells with squamous differentiation and with keratin pearl formation were identified predominantly in the superficial dermis, and mucinous cells were identified principally in the cystic lesion in the deep dermis. Interestingly, the additional feature of pagetoid cells was identified in the overlying epidermis. Both the mucinous cells in hidradenocarcinoma and pagetoid cells had intracytoplasmic mucin; however, they had different histopathologic findings and immunophenotypes. Mucinous cells in hidradenocarcinoma had small nuclei and abundant intracytoplasmic mucin presenting goblet cells with low rate of positive immunostaining for p53 and Ki67. In contrast, pagetoid cells had larger nuclei with less intracytoplasmic mucin. Both p53\u2010 and Ki67\u2010positive cells were increased in pagetoid cells. Additionally, mucinous cells in hidradenocarcinoma were <jats:styled-content style=\"fixed-case\">MUC1<\/jats:styled-content>(+)\/<jats:styled-content style=\"fixed-case\">MUC2<\/jats:styled-content>(\u2212)\/<jats:styled-content style=\"fixed-case\">MUC5AC<\/jats:styled-content>(+)\/<jats:styled-content style=\"fixed-case\">MUC6<\/jats:styled-content>(+), but pagetoid cells were <jats:styled-content style=\"fixed-case\">MUC1<\/jats:styled-content>(+; focal)\/<jats:styled-content style=\"fixed-case\">MUC2<\/jats:styled-content>(\u2212)\/<jats:styled-content style=\"fixed-case\">MUC5AC<\/jats:styled-content>(\u2212)\/<jats:styled-content style=\"fixed-case\">MUC6<\/jats:styled-content>(+; focal). The derivation of pagetoid cells is unclear; however, the localized small region of pagetoid cells over the hidradenocarcinoma in the present case may suggest a common histogenesis of these two malignant neoplasms.<\/jats:p>","DOI":"10.1111\/cup.12120","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T16:14:10Z","timestamp":1361808850000},"page":"503-508","source":"Crossref","is-referenced-by-count":8,"title":["Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells"],"prefix":"10.1111","volume":"40","author":[{"given":"Yumi","family":"Honda","sequence":"first","affiliation":[{"name":"Department of Surgical Pathology Kumamoto University Hospital  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Tanigawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Masuguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Ihn","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken\u2010ichi","family":"Iyama","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Kumamoto University Hospital  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,14]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"485","volume-title":"Neoplasms with eccrine differentiation","author":"Abenoza P","year":"1990"},{"key":"e_1_2_5_3_1","first-page":"687","volume-title":"Neoplasms with apocrine differentiation","author":"Requena L","year":"1997"},{"key":"e_1_2_5_4_1","first-page":"125","volume-title":"World Health Organization Classification of Tumours, pathology and genetics of skin tumours","author":"Requena L","year":"2006"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2008.01079.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2000.027008423.x"},{"key":"e_1_2_5_7_1","first-page":"43","article-title":"Vulvar sweat gland carcinoma","volume":"109","author":"Wick MR","year":"1985","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1983.tb06754.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.57.030195.003135"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00536.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.18"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195903\/04)12:2<286::AID-CNCR2820120212>3.0.CO;2-A"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000147397.08853.6f"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00645.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1996.tb01476.x"},{"key":"e_1_2_5_16_1","first-page":"781","article-title":"A case of clear cell hidradenoma with mucinous metaplasia in the forehead. 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