{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:59:02Z","timestamp":1791007142500,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T00:00:00Z","timestamp":1363996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>We report histopathological findings in a case of familial Mediterranean fever (<jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content>) syndrome with an erysipelas\u2010like erythema (<jats:styled-content style=\"fixed-case\">ELE<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">ELE<\/jats:styled-content> is the only pathognomic cutaneous manifestation of <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">ELE<\/jats:styled-content> is characterized by well\u2010demarcated, tender, erythematous and infiltrated plaques recurring on the same site and resolving spontaneously within 48\u201372\u2009h. <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> is a monogenic autoinflammatory syndrome highlighted by recurrent fever associated with polyserositis involving mainly the peritoneum, synovium and pleura. <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> results from a mutation of the <jats:styled-content style=\"fixed-case\">MEFV<\/jats:styled-content> gene, which encodes for pyrin, leading to Il\u20101\u03b2 activation and promoting neutrophil migration into the dermis. Histopathological findings in our case showed a sparse superficial perivascular and interstitial lymphocytic infiltrate admixed with some neutrophils, no eosinophils and mild papillary dermal edema. Venules and lymphatics were dilated, though no vasculitis was identified. Neutrophils are the most common cutaneous marker of autoinflammation, and cutaneous manifestations of monogenic autoinflammatory syndromes are represented by the spectrum of aseptic neutrophilic dermatoses. Neutrophils in the presence of recurrent fever and in the correct clinical context of recurrent erysipelas in the same site are a diagnostic clue for FMF.<\/jats:p>","DOI":"10.1111\/cup.12132","type":"journal-article","created":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T19:22:31Z","timestamp":1362165751000},"page":"585-590","source":"Crossref","is-referenced-by-count":16,"title":["Erysipelas\u2010like erythema of familial Mediterranean fever syndrome: a case report with emphasis on histopathologic diagnostic clues"],"prefix":"10.1111","volume":"40","author":[{"given":"Athanassios","family":"Kolivras","sequence":"first","affiliation":[{"name":"Department of Dermatology and Dermatopathology, Saint\u2010Pierre Hospital Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Provost","sequence":"additional","affiliation":[{"name":"Private practice  Aix en Provence France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis T.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oregon Health Sciences University  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000198006.65697.5b"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.5.e70"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07733.x"},{"key":"e_1_2_5_5_1","first-page":"163","article-title":"The multi\u2010face expression of familial Mediterranean fever in the child","volume":"10","author":"Rigante D","year":"2006","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2006.045"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2009.12.009"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken118"},{"key":"e_1_2_5_9_1","first-page":"179","article-title":"Autoinflammatory syndromes behind the scenes of recurrent fevers in children","volume":"15","author":"Rigante D","year":"2009","journal-title":"Med Sci Monit"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.3.392"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.002"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401023"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199808)41:8<1516::AID-ART31>3.0.CO;2-O"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328329d15e"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68430-4"},{"key":"e_1_2_5_16_1","first-page":"S67","article-title":"The prevalence of Beh\u00e7et's syndrome, familial Mediterranean fever, HLA\u2010B51 and MEFV gene mutations among ethnic Armenians living in Istanbul, Turkey","volume":"28","author":"Seyahi E","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken509"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000152370.84628.0c"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.12.010"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(96)80012-6"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800810633"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.103048"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01003.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087824"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0255-8"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04442.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.11.1275"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1390-z"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-004-1440-1"},{"key":"e_1_2_5_30_1","first-page":"607","article-title":"The cutaneous manifestations in children with familial Mediterranean fever (recurrent hereditary polyserositis). 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