{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:46:52Z","timestamp":1773449212997,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:00:00Z","timestamp":1368576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"Primary cutaneous CD4<\/jats:styled-content> positive small\/medium pleomorphic T\u2010cell lymphoma (SMPTCL<\/jats:styled-content>) represents a provisional subtype of primary cutaneous T\u2010cell lymphoma with indolent clinical course. A few aggressive fatal cases with increased proliferation rate and few infiltrating CD8<\/jats:styled-content> positive T\u2010cells have been reported. We describe a case of SMPTCL<\/jats:styled-content> with an increased proliferation rate, admixed CD30<\/jats:styled-content>\u2010positive large lymphoid cells, and few infiltrating CD8<\/jats:styled-content> positive T\u2010cells. The lymphoma cells were positive for CD3<\/jats:styled-content>, CD4<\/jats:styled-content>, CD2<\/jats:styled-content> and CD5<\/jats:styled-content>, and negative for CD8<\/jats:styled-content>. A subset of the lymphoma cells was positive for follicular helper T\u2010cell markers bcl\u20106 and PD<\/jats:styled-content>\u20101. There were approximately 20% CD30<\/jats:styled-content>\u2010positive large lymphoid cells, and Ki\u201067 showed a moderately high proliferation rate (\u223c40%), mostly in the large lymphoid cells. CD8<\/jats:styled-content> infiltrating T\u2010cells were few (<5%). The patient had an indolent disease with complete response to radiation therapy. To the best of our knowledge, this is the first reported case of SMPTCL<\/jats:styled-content> with an increased proliferation rate and large CD30<\/jats:styled-content>+ cells that followed an indolent clinical course.<\/jats:p>","DOI":"10.1111\/cup.12169","type":"journal-article","created":{"date-parts":[[2013,4,13]],"date-time":"2013-04-13T15:26:37Z","timestamp":1365866797000},"page":"720-724","source":"Crossref","is-referenced-by-count":17,"title":["Primary cutaneous CD4 positive small\/medium T\u2010cell lymphoma with high proliferation index and CD30<\/scp>\u2010positive large lymphoid cells"],"prefix":"10.1111","volume":"40","author":[{"given":"Ling","family":"Zhang","sequence":"first","affiliation":[{"name":"Hematopathology and Laboratory Medicine, H Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haipeng","family":"Shao","sequence":"additional","affiliation":[{"name":"Hematopathology and Laboratory Medicine, H Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"304","volume-title":"WHO classification of tumors of haematopoietic and lymphoid tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690210039007"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31819f19bb"},{"key":"e_1_2_4_6_1","first-page":"389","article-title":"Primary cutaneous small\u2010 to medium\u2010sized CD4+ pleomorphic T\u2010cell lymphoma: a retrospective case series and review of the provisional cutaneous lymphoma category","volume":"12","author":"Williams VL","year":"2011","journal-title":"Am J Clin Dermatol"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711720110"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318230df87"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.40"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-1960"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.07.028"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.3.800"},{"key":"e_1_2_4_13_1","first-page":"3637","article-title":"Prognostic factors in primary cutaneous lymphomas other than mycosis fungoides and the Sezary syndrome. 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