{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:12:26Z","timestamp":1791220346666,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T00:00:00Z","timestamp":1371600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>Antimalarials are commonly prescribed in medical practice for conditions such as rheumatoid arthritis, lupus erythematosus, as well as malaria. They are generally well\u2010tolerated, but side effects, although infrequent, are well known. The antimalarial chloroquine diphosphate may be associated with a bluish\u2010gray to black hyperpigmentation of the oral mucosa, mainly on the hard palate. In this report we described five additional cases of palate hyperpigmentation related to the chronic use of chloroquine diphosphate. Professionals must be aware of the adverse effects of antimalarials as chloroquine diphosphate in order to make the correct diagnosis and appropriate management of the patient. Early diagnosis of oral pigmentation by antimalarials may be of great relevance, because it might be an early sign of ocular involvement, and therefore it may be helpful to prevent further complications of antimalarial therapy for the patient.<\/jats:p>","DOI":"10.1111\/cup.12182","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T15:09:00Z","timestamp":1369840140000},"page":"833-838","source":"Crossref","is-referenced-by-count":22,"title":["Hard palate hyperpigmentation secondary to chronic chloroquine therapy: report of five cases"],"prefix":"10.1111","volume":"40","author":[{"given":"Bruno Augusto Benevenuto","family":"de Andrade","sequence":"first","affiliation":[{"name":"Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School University of Campinas (UNICAMP) Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Paiva","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School University of Campinas (UNICAMP) Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Ram\u00f4a","family":"Pires","sequence":"additional","affiliation":[{"name":"Oral Pathology, School of Dentistry State University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Terezinha Marques","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Department of Dentistry, College of Basic Sciences and Health Federal University of Vales do Jequitinhonha e Mucuri (UFVJM) Diamantina Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo Gabriel Moreira","family":"Falci","sequence":"additional","affiliation":[{"name":"Department of Dentistry, College of Basic Sciences and Health Federal University of Vales do Jequitinhonha e Mucuri (UFVJM) Diamantina Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan Roger","family":"dos Santos Silva","sequence":"additional","affiliation":[{"name":"Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School University of Campinas (UNICAMP) Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Agustin","family":"Vargas","sequence":"additional","affiliation":[{"name":"Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School University of Campinas (UNICAMP) Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacks","family":"Jorge","sequence":"additional","affiliation":[{"name":"Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School University of Campinas (UNICAMP) Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oslei Paes","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School University of Campinas (UNICAMP) Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,19]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.106340"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-011-0288-5"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03185.x"},{"key":"e_1_2_4_5_1","first-page":"327","article-title":"Pigmented lichenoid drug eruption secondary to chloroquine therapy: an unusual presentation in lower lip","volume":"60","author":"Moraes PC","year":"2011","journal-title":"Minerva 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