{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:42:37Z","timestamp":1784698957525,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T00:00:00Z","timestamp":1376438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>The recently proposed entity of cutaneous follicular helper T (T<jats:sub>FH<\/jats:sub>) cell lymphoma (<jats:styled-content style=\"fixed-case\">CT<jats:sub>FH<\/jats:sub>CL<\/jats:styled-content>) harbors distinct clinical and histopathologic features. Here, diagnostic pitfalls are exemplified in a case report and by review of the literature. A 45\u2010year\u2010old patient developed rapidly growing nodules and plaques on upper arms and buttocks, which were initially misdiagnosed as primary cutaneous follicle center B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">CFCL<\/jats:styled-content>). Consequently, systemic therapy with rituximab failed and consecutive skin biopsies revealed <jats:styled-content style=\"fixed-case\">CT<jats:sub>FH<\/jats:sub>CL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CD3<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">CD10<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101+bcl6+<jats:styled-content style=\"fixed-case\">ICOS<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">CXCL13<\/jats:styled-content>+). Interestingly, the prima vista <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101\u2010positive and <jats:styled-content style=\"fixed-case\">CD10<\/jats:styled-content>\u2010positive tumor cells lost <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101 expression in follow\u2010up biopsies while retaining <jats:styled-content style=\"fixed-case\">CD10<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">ICOS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CXCL13<\/jats:styled-content> expression. All biopsy specimens displayed an identical clonal T\u2010cell population. Initially, nodules were controlled by local radiotherapy and oral psoralen combined with ultraviolet A (<jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>) therapy. However, disease recurred and progressed rapidly with disseminated nodules. Treatment with bexarotene, methotrexate and polychemotherapy failed to stop disease progression. Finally, modified total skin electron beam radiation resulted in complete remission. Disease stabilized on maintenance therapy with bexarotene in combination with ultraviolet A (<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>) therapy. The case highlights that because of concomitant B\u2010cell stimulation, <jats:styled-content style=\"fixed-case\">CT<jats:sub>FH<\/jats:sub>CL<\/jats:styled-content> clinicopathologically is prone to be mistaken for <jats:styled-content style=\"fixed-case\">CFCL<\/jats:styled-content>. Importantly, <jats:styled-content style=\"fixed-case\">CT<jats:sub>FH<\/jats:sub>CL<\/jats:styled-content> might lose <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101 while retaining <jats:styled-content style=\"fixed-case\">CD10<\/jats:styled-content> expression in later stages, which may lead to confusion in distinguishing <jats:styled-content style=\"fixed-case\">CT<jats:sub>FH<\/jats:sub>CL<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">CFCL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cup.12204","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T12:57:35Z","timestamp":1375102655000},"page":"903-908","source":"Crossref","is-referenced-by-count":27,"title":["Primary cutaneous follicular helper T\u2010cell lymphoma: diagnostic pitfalls of this new lymphoma subtype"],"prefix":"10.1111","volume":"40","author":[{"given":"Kristina","family":"Buder","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Hospital W\u00fcrzburg W\u00fcrzburg Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lid\u00eda M.","family":"Poppe","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Hospital W\u00fcrzburg W\u00fcrzburg Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva B.","family":"Br\u00f6cker","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Hospital W\u00fcrzburg W\u00fcrzburg Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Goebeler","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Hospital W\u00fcrzburg W\u00fcrzburg Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rosenwald","sequence":"additional","affiliation":[{"name":"Institute of Pathology University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Geissinger","sequence":"additional","affiliation":[{"name":"Institute of Pathology University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kerstan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Hospital W\u00fcrzburg W\u00fcrzburg Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-310342"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.05.002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03498.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.3269"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.1545"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.124"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12022"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31818e52fe"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318230df87"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181af7dee"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:48:09Z","timestamp":1696308489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,14]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/cup.12204"],"URL":"https:\/\/doi.org\/10.1111\/cup.12204","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,14]]}}}