{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:41:18Z","timestamp":1791844878560,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T00:00:00Z","timestamp":1381881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>Patients with hypopigmented mycosis fungoides (<jats:styled-content style=\"fixed-case\">HMF<\/jats:styled-content>) present at a younger age than those with classic <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>. Our goal was to describe the clinical presentation, histopathologic features and long\u2010term outcome in patients who developed <jats:styled-content style=\"fixed-case\">HMF<\/jats:styled-content> before the age of 21. It was observed that among 69 pediatric patients diagnosed with <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> between 1992 and 2010, 50 had <jats:styled-content style=\"fixed-case\">HMF<\/jats:styled-content>. Thirty\u2010five patients had clinical follow\u2010up. There were 37 males and 32 females with a mean age of 13.6 years. Most patients were African American or Hispanic and presented with multiple hypopigmented patches. All biopsies showed epidermotropism of T\u2010lymphocytes, whereas fibroplasia and lichenoid infiltrate were variable. All specimens tested were <jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content>+. Treatment modalities included topical steroids, narrow band ultraviolet B and psoralen and ultraviolet A. <jats:styled-content style=\"fixed-case\">HMF<\/jats:styled-content> patients were followed for &lt;1\u201312 years. Most children responded to treatment, but recurrence rates were high. One patient progressed to plaque\/tumor stage. Others did not progress; however, many were lost to follow\u2010up. We present a large cohort of children with <jats:styled-content style=\"fixed-case\">HMF<\/jats:styled-content> and report on the features of disease and progression. A major difference in histology of <jats:styled-content style=\"fixed-case\">HMF<\/jats:styled-content> was lack of fibroplasia and lichenoid infiltrate, probably because of presentation in the early patch stage. Most patients have a waxing\u2010and\u2010waning course and relapse after discontinuation of therapy, requiring repetitive treatment.<\/jats:p>","DOI":"10.1111\/cup.12217","type":"journal-article","created":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T17:36:36Z","timestamp":1377106596000},"page":"924-934","source":"Crossref","is-referenced-by-count":80,"title":["Hypopigmented mycosis fungoides in childhood and adolescence: a long\u2010term retrospective study"],"prefix":"10.1111","volume":"40","author":[{"given":"Ekaterina","family":"Castano","sequence":"first","affiliation":[{"name":"Department of Pathology Montefiore Medical Center Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Glick","sequence":"additional","affiliation":[{"name":"Department of Dermatology Downstate Medical Center Brooklyn NY 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