{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:14:43Z","timestamp":1696396483353},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T00:00:00Z","timestamp":1381190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple lymphoma subtypes occurring within one patient is rare in the context of B\u2010cell lymphoma, and only few such cases have been reported in association with primary cutaneous marginal zone lymphoma (<jats:styled-content style=\"fixed-case\">PCMZL<\/jats:styled-content>). We herein describe the case of a 43\u2010year\u2010old patient who was diagnosed with <jats:styled-content style=\"fixed-case\">PCMZL<\/jats:styled-content> and subsequently developed a clonally unrelated nodal marginal zone lymphoma (<jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content>). At the time of diagnosis of <jats:styled-content style=\"fixed-case\">PCMZL<\/jats:styled-content>, multiple skin lesions were present. The atypical lymphoid infiltrate showed monotypic expression of immunoglobulin light chain lambda and heavy chain (<jats:styled-content style=\"fixed-case\">IgM<\/jats:styled-content>) on immunohistochemistry and an identical B\u2010cell clone. No sign of systemic lymphoma was present in staging examinations. Complete remission was achieved utilizing rituximab. After a 3\u2010year clinical course of repetitive cutaneous relapses and remissions, the patient additionally developed nodal lymphoma involvement by <jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content> which, however, harbored an immunophenotype and a genetic clone distinct from the cutaneous lymphoma counterpart. Therefore, the rare occurrence of two different types of <jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content> with sequential evolution was diagnosed. In this uncommon case, we hypothesize that selective immunoglobulin A deficiency may play a promoting role for the metachronous development of the two <jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content> that occurred in our patient.<\/jats:p>","DOI":"10.1111\/cup.12230","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T18:13:57Z","timestamp":1379009637000},"page":"1035-1041","source":"Crossref","is-referenced-by-count":6,"title":["Primary cutaneous marginal zone lymphoma with sequential development of nodal marginal zone lymphoma in a patient with selective immunoglobulin A deficiency"],"prefix":"10.1111","volume":"40","author":[{"given":"Marion","family":"Wobser","sequence":"first","affiliation":[{"name":"Department of Dermatology University Clinic Wuerzburg Wuerzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kerstan","sequence":"additional","affiliation":[{"name":"Department of 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