{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:41:54Z","timestamp":1769596914311,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T00:00:00Z","timestamp":1381190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Aleukemic cutaneous myeloid sarcoma (<jats:styled-content style=\"fixed-case\">CMS<\/jats:styled-content>) represents an important yet rare entity denoting the presence of a cutaneous myeloid leukemic infiltrate without concurrent peripheral blood or bone marrow disease. The clinicopathologic diagnosis remains elusive due to isolated skin findings and variable immunostaining. Cytogenetic and molecular findings have infrequently been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five patients with <jats:styled-content style=\"fixed-case\">CMS<\/jats:styled-content> were identified in the Massachusetts General Hospital pathology database between 2004 and 2012. Patients were excluded if concurrent blood or marrow acute myeloid leukemia (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>), myelodysplastic syndrome or lymphoproliferative disorder were diagnosed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three patients were identified: a neonate with recurrent <jats:styled-content style=\"fixed-case\">CMS<\/jats:styled-content> and marrow disease that never met diagnostic criteria for <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content> and two patients relapsing as <jats:styled-content style=\"fixed-case\">CMS<\/jats:styled-content> without concurrent blood or marrow disease following chemotherapy\u2010induced complete remission. Histology showed atypical mononuclear cell interstitial dermal infiltrates. All cases were <jats:styled-content style=\"fixed-case\">CD68<\/jats:styled-content>+, lysozyme+ and <jats:styled-content style=\"fixed-case\">CD117<\/jats:styled-content>\u2212; one of two were <jats:styled-content style=\"fixed-case\">CD34<\/jats:styled-content>+; two of three were myeloperoxidase negative. 11q23 rearrangement, t(1;14), <jats:italic><jats:styled-content style=\"fixed-case\">NPM1<\/jats:styled-content><\/jats:italic> (nucleophosmin I), <jats:italic><jats:styled-content style=\"fixed-case\">FLT3\u2010ITD<\/jats:styled-content><\/jats:italic> (Fms\u2010like tyrosine kinase 3\u2010internal tandem duplication), and novel <jats:italic><jats:styled-content style=\"fixed-case\">FLT3<\/jats:styled-content><\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">D835<\/jats:styled-content> mutations were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An isolated atypical cutaneous infiltrate may represent aleukemic <jats:styled-content style=\"fixed-case\">CMS<\/jats:styled-content> and should prompt a search for other extramedullary sites of involvement. Immunohistochemistry, molecular and cytogenetic studies can help differentiate aleukemic <jats:styled-content style=\"fixed-case\">CMS<\/jats:styled-content> from benign and malignant, monocytic and histiocytic mimickers, and may potentially indicate therapy and prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12231","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T18:11:35Z","timestamp":1379009495000},"page":"996-1005","source":"Crossref","is-referenced-by-count":29,"title":["Aleukemic cutaneous myeloid sarcoma"],"prefix":"10.1111","volume":"40","author":[{"given":"Amir","family":"Aboutalebi","sequence":"first","affiliation":[{"name":"Department of Dermatology Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.","family":"Korman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Harvard Medical School Boston MA 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