{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:12:26Z","timestamp":1785683546666,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T00:00:00Z","timestamp":1381536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Background<\/jats:title>CD4<\/jats:styled-content>+ small\/medium\u2010sized pleomorphic T\u2010cell lymphoma (SMPTCL<\/jats:styled-content>) is a controversial primary cutaneous lymphoma, in which the candidate neoplastic cells express a follicular T\u2010helper phenotype. We describe 16 cases of SMPTCL<\/jats:styled-content> and compare expression of PD<\/jats:styled-content>\u20101, CXCL<\/jats:styled-content>\u201013 and ICOS<\/jats:styled-content> in these tumors with 40 dermatitis cases.<\/jats:p><\/jats:sec>Methods<\/jats:title>Histopathologic examination and immunocytochemistry were performed for 16 tumors and 40 assorted dermatitis cases.<\/jats:p><\/jats:sec>Results<\/jats:title>All but one patient presented with solitary lesions. Each biopsy revealed a dense nodular non\u2010epitheliotropic infiltrate of atypical T\u2010cells. Neoplastic cells were CD3<\/jats:styled-content>+\/CD4<\/jats:styled-content>+\/CD8<\/jats:styled-content>(\u2212)\/CD30<\/jats:styled-content>(\u2212). Cutaneous recurrence occurred in one patient over a median follow up of 8\u2009months (range 5\u201336). All tumors widely expressed PD<\/jats:styled-content>\u20101 and ICOS<\/jats:styled-content> to a lesser extent. CXCL<\/jats:styled-content>\u201013 stained much fewer cells. Of the dermatitis cases, PD<\/jats:styled-content>\u20101 (most numerous) and ICOS<\/jats:styled-content> labeled lymphoid cells in all cases, albeit fewer than in the tumors, and CXCL<\/jats:styled-content>\u201013 was negative in 32. A rosette pattern of PD<\/jats:styled-content>\u20101 expression was identified in all the SMPTCL<\/jats:styled-content> cases but not in dermatitis.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>There remains uncertainty about the appropriate nosological status of SMPTCL<\/jats:styled-content>, which some authors consider to be a pseudolymphoma. However, this study suggests a significant difference in the prevalence and pattern of follicular T\u2010helper cell markers between this tumor and lymphoid proliferations known to be reactive.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12234","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T18:10:57Z","timestamp":1379009457000},"page":"1006-1013","source":"Crossref","is-referenced-by-count":50,"title":["Evaluation of follicular T\u2010helper cells in primary cutaneous CD4<\/scp>+ small\/medium pleomorphic T\u2010cell lymphoma and dermatitis"],"prefix":"10.1111","volume":"40","author":[{"given":"Mina S.","family":"Ally","sequence":"first","affiliation":[{"name":"St John's Institute of Dermatology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranganna Y.","family":"Prasad Hunasehally","sequence":"additional","affiliation":[{"name":"Princess of Wales Hospital Bridgend 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T\u2010cell lymphoma; dermatopathological features in a series of 40 cases","volume":"24","author":"Cardoso J","year":"2011","journal-title":"Modern Pathol Suppl"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200401000-00005"},{"key":"e_1_2_5_29_1","unstructured":"OrtonneN KebirF ChabyG et al. 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