{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T23:50:59Z","timestamp":1717458659671},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T00:00:00Z","timestamp":1380758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Background<\/jats:title>Basal cell carcinoma (BCC<\/jats:styled-content>) has a characteristic stroma, but less is known about the dermal characteristics associated with melanoma in situ<\/jats:italic> (MIS<\/jats:styled-content>) and actinic keratosis (AK<\/jats:styled-content>).<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>Dermal changes were studied in 301 specimens of AK<\/jats:styled-content>, BCC<\/jats:styled-content> and MIS<\/jats:styled-content>. Subsequently, blinded images of dermal changes from 90 randomly selected cases of those entities were used to assess the predictive value of the dermal changes. Agreement with the final diagnosis was calculated using kappa coefficient (\u03ba).<\/jats:p><\/jats:sec>Results<\/jats:title>Fibromyxoid stroma was present in 82% of BCC<\/jats:styled-content> cases; fibrous stroma was seen in 25% of BCC<\/jats:styled-content>, 58% of MIS<\/jats:styled-content> and 35.6% of AK<\/jats:styled-content> specimens (p\u2009<\u20090.05). A lichenoid inflammatory infiltrate was frequently associated with AK<\/jats:styled-content> and a perifollicular infiltrate with periadnexal fibrosis with MIS<\/jats:styled-content>. Blinded evaluation of images of the dermal changes associated with the tumors yielded the correct diagnosis in (54.4, 41.1 and 27.8%; average 41.2%) by the three appraisers. Coefficient of agreement in blinded imaged evaluation with the actual diagnosis was higher in the BCC<\/jats:styled-content> and MIS<\/jats:styled-content> compared with AK<\/jats:styled-content> (\u03ba\u2009=\u20090.37, p\u2009=\u20090.0001; \u03ba\u2009=\u20090.2, p\u2009=\u20090.0005 and \u03ba\u2009=\u2009\u22120.06, p\u2009=\u20090.84, respectively).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Dermal features may be helpful in predicting the correct diagnosis when tumor is not visible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12235","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T18:14:49Z","timestamp":1379009689000},"page":"1014-1020","source":"Crossref","is-referenced-by-count":8,"title":["Dermal changes in superficial basal cell carcinoma, melanoma in situ<\/i> and actinic keratosis and their implications"],"prefix":"10.1111","volume":"40","author":[{"given":"Viktoryia","family":"Kazlouskaya","sequence":"first","affiliation":[{"name":"Ackerman Academy of Dermatopathology New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saurabh","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Pathology Dartmouth\u2010Hitchcock Medical Center Lebanon NH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Dermatology La Princesa University Hospital Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Nguyen","family":"Wu","sequence":"additional","affiliation":[{"name":"Ackerman Academy of Dermatopathology New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Shvartsbeyn","sequence":"additional","affiliation":[{"name":"Department of Pathology New York University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Shengli","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology Shandong Provincial Institute of Dermatology and Venereology Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Gui","sequence":"additional","affiliation":[{"name":"Section of Biostatics and Epidemiology Department of Family and Community Medicine, Geisel School of Medicine Lebanon NH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk M.","family":"Elston","sequence":"additional","affiliation":[{"name":"Ackerman Academy of Dermatopathology New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2011.23.2.125"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200608000-00002"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.10.650"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.103344"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.5858\/2009-0538-RA.1","article-title":"Lentiginous melanoma","volume":"135","author":"King R","year":"2011","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)80251-X"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7985-1943-5_47"},{"key":"e_1_2_5_9_1","first-page":"432","article-title":"How to use and interpret interval likelihood ratios","volume":"31","author":"Sonis J","year":"1999","journal-title":"Fam Med"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200009000-00014"},{"key":"e_1_2_5_12_1","first-page":"256","volume-title":"Clues to diagnosis in dermatopathology","author":"Ackerman A","year":"1992"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200102000-00013"},{"key":"e_1_2_5_14_1","first-page":"625","volume-title":"Neoplasms with follicular differentiation","author":"Ackerman A","year":"2001"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-12-1"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12560782"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.142"},{"key":"e_1_2_5_18_1","first-page":"329","article-title":"Differential expression of basic fibroblast growth factor (bFGF) in melanocytic lesions demonstrated by in situ hybridization. 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