{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:12:24Z","timestamp":1696396344245},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T00:00:00Z","timestamp":1384128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Clear cell tumors of the skin are observed in a wide variety of benign and malignant conditions with different histogenesis, sharing the presence of cells with abundant clear cytoplasm. Herein, we report the clinicopathologic features of a healthy young patient affected by asymptomatic, eruptive and disseminated, benign clear cell dermal tumors since early infancy. Neither family history nor genetic testing and counseling provided further useful information. The lesions were mostly confined to the face and lower left extremity with pink teleangiectatic papules and small nodules. Over a 4\u2010year period, a total of 16 different cutaneous lesions were biopsied and histopathologic and immunohistochemical studies carried out; an additional lesion was also removed for electron microscopy examination. Histopathology evidenced multiple perivascular growths of spindle to oval and round cells intermingled with clear\/granular cells throughout the dermis, with prominent desmoplasia and numerous capillary\u2010like vessels with focal hemangiopericytoma\u2010like features. Immunohistochemical neoplastic cells were uniformly positive for h\u2010caldesmon and focally smooth muscle \u03b1\u2010actin and <jats:styled-content style=\"fixed-case\">CD13<\/jats:styled-content> indicating myoid differentiation whereas the consistent diffuse cytoplasmic staining for lysosome antigen, such as <jats:styled-content style=\"fixed-case\">CD68PG\u2010M1<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NKI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">C3<\/jats:styled-content> along with the ultrastructural findings supported the view of a lysosome\u2010mediated apoptotic process. The differential diagnosis with other clear cell cutaneous neoplasms is discussed.<\/jats:p>","DOI":"10.1111\/cup.12240","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:26:05Z","timestamp":1381541165000},"page":"123-133","source":"Crossref","is-referenced-by-count":4,"title":["Eruptive dermal clear cell desmo\u2010plastic mesenchymal tumors with perivascular myoid differentiation in a young boy. A clinical, histopathologic, immunohistochemical and electron microscopy study of 17 lesions"],"prefix":"10.1111","volume":"41","author":[{"given":"Carlo","family":"Tomasini","sequence":"first","affiliation":[{"name":"Dermatopathology Section Azienda Ospedaliera Citt\u00e0 della Salute e della Scienza Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Metze","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital M\u00fcnster M\u00fcnster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Osella\u2010Abate","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic, Department of Medical Science University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Novelli","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic, Department of Medical Science University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"Kutzner","sequence":"additional","affiliation":[{"name":"Dermatopathologische Gemeinschaftspraxis Friedrichshafen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1984.tb00369.x"},{"key":"e_1_2_5_3_1","first-page":"40","article-title":"Clear cell tumors of the skin","volume":"13","author":"Suster S","year":"1996","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3182106d28"},{"key":"e_1_2_5_5_1","first-page":"110","article-title":"Fibrous papule with clear fibrocytes","volume":"3","author":"Soyer HP","year":"1997","journal-title":"Dermatopathol Pract Concep"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02105.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31815604ab"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200408000-00002"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199604000-00013"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02192.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.025577"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1309\/QHD6YFN81KQXUUH6"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.1"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200607040-00010"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00631.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e318182a8e4"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02192.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181c98f89"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70153-K"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3180332462"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000171608.01552.77"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02160.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109359"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2008.01038.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02593544"},{"key":"e_1_2_5_26_1","first-page":"269","article-title":"Microvascular pericytes: a review of their morphological and functional characteristics","volume":"6","author":"D\u00edaz\u2010Flores L","year":"1991","journal-title":"Histol Histopathol"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.07.001"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194207000-00004"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-6053(06)80005-0"},{"key":"e_1_2_5_30_1","first-page":"221","article-title":"Hemangiopericytoma: histopathological pattern or clinicopathologic entity?","volume":"12","author":"Nappi O","year":"1995","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02290.x"},{"key":"e_1_2_5_32_1","first-page":"888","article-title":"Lysosomes and autophagy in cell death control","volume":"5","author":"Kroemer G","year":"2005","journal-title":"Nature"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02447"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12240","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:36:18Z","timestamp":1696340178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,11]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/cup.12240"],"URL":"https:\/\/doi.org\/10.1111\/cup.12240","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,11]]}}}