{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T17:24:10Z","timestamp":1785691450075,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T00:00:00Z","timestamp":1383091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Background<\/jats:title>Cutaneous CD8<\/jats:styled-content>+<\/jats:sup> CD30<\/jats:styled-content>+<\/jats:sup> lymphoproliferative lesions are difficult to classify and encompass entities that follow a benign course to overt lymphoma. In order to identify histopathologic criteria for lesions in this spectrum, a series of such cases was reviewed.<\/jats:p><\/jats:sec>Methods<\/jats:title>Twenty\u2010eight biopsies from 27 patients with CD8<\/jats:styled-content>+<\/jats:sup> CD30<\/jats:styled-content>+<\/jats:sup> cutaneous lymphoid proliferations were evaluated.<\/jats:p><\/jats:sec>Results<\/jats:title>Seventeen cases were classified as lymphomatoid papulosis (LyP<\/jats:styled-content>) \u2018type D\u2019, eight as cutaneous anaplastic large cell lymphoma (C\u2010ALCL<\/jats:styled-content>) and two as CD8<\/jats:styled-content>+<\/jats:sup> mycosis fungoides (MF<\/jats:styled-content>) with CD30<\/jats:styled-content> expression. Features of LyP<\/jats:styled-content> included spongiosis and\/or parakeratosis (90%), epidermotropism by large lymphocytes (90%), with (80%) or without (10%) small lymphocytes; wedge\u2010shaped infiltrate (70%) with perivascular (100%) and interstitial (80%) pattern; and relative uniformity of CD30<\/jats:styled-content>+<\/jats:sup> large atypical cells (90%). C\u2010ALCL<\/jats:styled-content> was characterized by ulceration (63%), epidermotropism restricted to small lymphocytes (100%), marked density (63%) and pleomorphism (62%) of CD30<\/jats:styled-content>+<\/jats:sup> large atypical cells, and at least focal extension of infiltrate to subcutaneous tissue (88%). CD8<\/jats:styled-content>+<\/jats:sup> CD30<\/jats:styled-content>+<\/jats:sup> MF<\/jats:styled-content> had vacuolar interface change and a lichenoid pattern (100%).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We concur with previous authors that distinction of CD8<\/jats:styled-content>+<\/jats:sup> LyP<\/jats:styled-content> from lymphoma in its differential diagnosis is difficult based on histopathology alone. Nonetheless, we propose that certain histopathologic clues may be helpful in this differential diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12243","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:28:38Z","timestamp":1381544918000},"page":"88-100","source":"Crossref","is-referenced-by-count":55,"title":["The differential diagnosis of CD8\u2010positive (\u201ctype D\u201d) lymphomatoid papulosis"],"prefix":"10.1111","volume":"41","author":[{"given":"Elizabeth","family":"McQuitty","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Curry","sequence":"additional","affiliation":[{"name":"Department of Pathology MD Anderson Cancer Center Houston TX USA"},{"name":"Department of Dermatology MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Tetzlaff","sequence":"additional","affiliation":[{"name":"Department of Pathology MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor G.","family":"Prieto","sequence":"additional","affiliation":[{"name":"Department of Pathology MD Anderson Cancer Center Houston TX USA"},{"name":"Department of Dermatology MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Duvic","sequence":"additional","affiliation":[{"name":"Department of Dermatology MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Torres\u2010Cabala","sequence":"additional","affiliation":[{"name":"Department of Pathology MD Anderson Cancer Center Houston TX USA"},{"name":"Department of Dermatology MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65144-9"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e75356"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.05.014"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/NNV4L5G5A0KF1T06"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200404000-00009"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2003.20211.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1990.tb01072.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1001\/archderm.1968.01610070029004","article-title":"Lymphomatoid papulosis. 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