{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:17:17Z","timestamp":1789564637964,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T00:00:00Z","timestamp":1384387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary cutaneous T\u2010cell lymphomas (<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>) comprise a heterogeneous group of neoplasms with diverse clinical behavior. Mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>) is the most common type of <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>. Immunophenotypical shift during progression of the disease is a rare event and its significance is unknown. We present three primary <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content> cases that showed an immunophenotypical shift and poor prognosis. Conventional hematoxylin\/eosin and immunohistochemical\u2010stained sections were examined in all the cases. Molecular analysis for rearrangement of the T\u2010cell receptor (<jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>) gene was performed in two cases. One case was classified as <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>, while the other two lacked epidermotropism, and were considered primary cutaneous peripheral T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>. Two cases were <jats:styled-content style=\"fixed-case\">CD3<\/jats:styled-content>+\/<jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content>+ and one case was <jats:styled-content style=\"fixed-case\">CD3<\/jats:styled-content>+\/<jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content>+ at diagnosis. The first two patients suffered many relapses and eventually, new <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content> lesions with a <jats:styled-content style=\"fixed-case\">CD3<\/jats:styled-content>+\/<jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content>+ phenotype were observed. Both cases revealed identical clonal <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> rearrangements on the initial and late lesions, supporting the interpretation of a single clonal proliferation with different phenotypes. The third case progressed with skin recurrences and pulmonary lesions with a predominant <jats:styled-content style=\"fixed-case\">CD3<\/jats:styled-content>+\/<jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content>+\/<jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content>\u2212 phenotype. All cases manifested poor prognosis and two patients died of lymphoma. Immunophenotypical shift between <jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content> seems to be a rare phenomenon that may be associated with disease progression.<\/jats:p>","DOI":"10.1111\/cup.12252","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T18:23:00Z","timestamp":1382552580000},"page":"51-57","source":"Crossref","is-referenced-by-count":24,"title":["Immunophenotypic shift of <scp>CD4<\/scp> and <scp>CD8<\/scp> antigen expression in primary cutaneous T\u2010cell lymphomas: a clinicopathologic study of three cases"],"prefix":"10.1111","volume":"41","author":[{"given":"Phyu Phyu","family":"Aung","sequence":"first","affiliation":[{"name":"National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fina","family":"Climent","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Muzzafar","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center The University of Texas Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Curry","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center The University of Texas Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyur P.","family":"Patel","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center The University of Texas Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio","family":"Servitje","sequence":"additional","affiliation":[{"name":"Hospital Universitari de Bellvitge Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor G.","family":"Prieto","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center The University of Texas Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Duvic","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center The University of Texas Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine S.","family":"Jaffe","sequence":"additional","affiliation":[{"name":"National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Torres\u2010Cabala","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center The University of Texas Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.12.1692"},{"key":"e_1_2_5_3_1","first-page":"296","volume-title":"Mycosis fungoides. 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