{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:06:31Z","timestamp":1770822391002,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,23]],"date-time":"2013-11-23T00:00:00Z","timestamp":1385164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Numbers of programmed death\u20101 (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101) positive T cells have prognostic significance in some types of nodal B\u2010cell lymphomas, but data on <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101 expression in cutaneous B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">CBCL<\/jats:styled-content>) are few. In this study we determined the expression and distribution of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101 on neoplastic B cells and reactive T cells in skin sections from primary <jats:styled-content style=\"fixed-case\">CBCLs<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>By means of immunohistochemical staining, <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101 expression was investigated in skin biopsies from 10 patients with primary cutaneous marginal zone lymphoma (<jats:styled-content style=\"fixed-case\">PCMZL<\/jats:styled-content>), 18 patients with primary cutaneous follicle center lymphoma (<jats:styled-content style=\"fixed-case\">PCFCL<\/jats:styled-content>) and 12 patients with primary cutaneous diffuse large B\u2010cell lymphoma\u2013leg type (<jats:styled-content style=\"fixed-case\">PCDLBCL\u2013LT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neoplastic B cells were negative for <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101 in all cases, except for two cases of <jats:styled-content style=\"fixed-case\">PCDLBCL\u2013LT<\/jats:styled-content>. The frequency of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101<jats:sup>+<\/jats:sup> T cells was significantly higher in <jats:styled-content style=\"fixed-case\">PCFCL<\/jats:styled-content> than in <jats:styled-content style=\"fixed-case\">PCMZL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PCDLBCL\u2013LT<\/jats:styled-content>, accounting for 20, 10 and 3% of the total number of infiltrating cells, and 60, 20 and 15% of the total number of <jats:styled-content style=\"fixed-case\">CD3<\/jats:styled-content><jats:sup>+<\/jats:sup> T cells, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101 is rarely expressed by the neoplastic B cells in <jats:styled-content style=\"fixed-case\">CBCL<\/jats:styled-content>. High percentages of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101<jats:sup>+<\/jats:sup> T cells, particularly if found outside germinal centers, support a diagnosis of <jats:styled-content style=\"fixed-case\">PCFCL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12254","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T18:17:44Z","timestamp":1382552264000},"page":"14-21","source":"Crossref","is-referenced-by-count":22,"title":["Programmed death\u20101 expression in cutaneous B\u2010cell lymphoma"],"prefix":"10.1111","volume":"41","author":[{"given":"Fatma","family":"\u00c7etin\u00f6zman","sequence":"first","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center Leiden The Netherlands,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianne","family":"Koens","sequence":"additional","affiliation":[{"name":"Department of Pathology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patty M.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Pathology Leiden University Medical Center Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rein","family":"Willemze","sequence":"additional","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center Leiden The Netherlands,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00923.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05919.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101400"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1877"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10864"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.11.012"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/404069"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.0513"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2487"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.08.015"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.4766"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2010.09.022"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12579"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e5060a"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318230df87"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.2089"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035178"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000209855.28282.ce"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2011.03.003"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31818e52fe"},{"key":"e_1_2_5_23_1","volume-title":"WHO classification of tumors\u2010haematopoietic and lymphoid tissues","author":"Swerdlow SH","year":"2008"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12254","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:00:02Z","timestamp":1696327202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,23]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/cup.12254"],"URL":"https:\/\/doi.org\/10.1111\/cup.12254","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,23]]}}}