{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:19:53Z","timestamp":1777713593374,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T00:00:00Z","timestamp":1386028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hypopigmentation in hypopigmented mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>) is thought to result from the action of <jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content>+ cells on melanocytes. Here, we investigated the immunophenotype and melanocytic markers in hypopigmented <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Specimens of hypopigmented lesions and normal skin from 18 patients with hypopigmented <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> and specimens of non\u2010hypopigmented lesions from 8 patients with classic\/conventional <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> were subjected to neoplastic immunophenotyping and melanocyte immunostaining with Melan\u2010A, tyrosinase, stem cell factor receptor (<jats:styled-content style=\"fixed-case\">CD117<\/jats:styled-content>) and microphthalmia\u2010associated transcription factor (<jats:styled-content style=\"fixed-case\">MiTF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content>+ immunophenotype was more common in hypopigmented <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> lesions (14\/18) than in conventional <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> lesions (1\/8, p\u2009=\u20090.0033). There was a main effect of specimen type (hypopigmented <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> lesion, hypopigmented <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> normal skin, conventional <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> lesion) on the number of melanocytes stained with Melan\u2010A (median number\/mm basal membrane, 1.97 vs. 4.77 vs. 5.42, respectively, p\u2009=\u20090.0046), tyrosinase (2.19 vs. 4.02 vs. 5.26, p\u2009=\u20090.0114), <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>117 (4.29 vs. 7.81 vs. 5.45, p\u2009=\u20090.0064), and <jats:styled-content style=\"fixed-case\">MiTF<\/jats:styled-content> (2.75 vs. 4.43 vs. 4.98, p\u2009=\u20090.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results confirm previous findings of fewer melanocytes and <jats:styled-content style=\"fixed-case\">CD117<\/jats:styled-content>\u2010positive melanocytes in hypopigmented <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> and showed reduced <jats:styled-content style=\"fixed-case\">MiTF<\/jats:styled-content> identification, which is crucial for the function and survival of melanocytes. Thus cytotoxic <jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content>+ cell action may determine <jats:styled-content style=\"fixed-case\">CD117<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MiTF<\/jats:styled-content> dysfunction, causing hypopigmentation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12262","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T08:24:42Z","timestamp":1384331082000},"page":"101-107","source":"Crossref","is-referenced-by-count":22,"title":["Loss of melanocytes in hypopigmented mycosis fungoides: a study of 18 patients"],"prefix":"10.1111","volume":"41","author":[{"given":"Fabricio C.","family":"Furlan","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna A.","family":"de Paula Pereira","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz F.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Sanches","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt242"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)00907-1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200204000-00006"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11780"},{"key":"e_1_2_5_6_1","first-page":"17","article-title":"Vitiligo vs. hypopigmented mycosis fungoides (histopathological and immunohistochemical study, univariate analysis)","volume":"16","author":"El\u2010Darouti MA","year":"2006","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12217"},{"key":"e_1_2_5_8_1","first-page":"133","article-title":"Hypopigmented mycosis fungoides: a report of 7 cases and review of the literature","volume":"67","author":"Stone ML","year":"2001","journal-title":"Cutis"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00203.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1982.tb14700.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800644"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1538"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24826"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2009.00653.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.29"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.18.6752"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04368.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03851.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198608000-00009"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91337-8"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12262","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:35:59Z","timestamp":1696340159000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,3]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/cup.12262"],"URL":"https:\/\/doi.org\/10.1111\/cup.12262","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,3]]}}}