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Two patients were female and two male, aged 50\u201374\u2009years (mean: 64.5\u2009years), each with a solitary painless, slowly enlarging, non\u2010ulcerated cutaneous nodule of 3\u201312\u2009months duration (mean: 9\u2009months). The lesions were on the scalp (n\u2009=\u20093) and trunk (n\u2009=\u20091), and ranged in greatest dimension from 0.5 to 2.5\u2009cm. The distinction from other microscopically similar entities, and the interpretation of origination from gastrointestinal, pancreatic or respiratory system primaries, was made clinically, or was based on the morphological features and the immunohistochemical profile. One patient died of the disease progression after 36\u2009months whereas two patients are alive with significant disease progression after 24 and 60\u2009months. Metastatic neuroendocrine tumor should be considered in the differential diagnosis of cutaneous tumors with neuroendocrine morphology even in patients with no known history of visceral malignancy.<\/jats:p>","DOI":"10.1111\/cup.12263","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T08:27:29Z","timestamp":1384331249000},"page":"113-122","source":"Crossref","is-referenced-by-count":25,"title":["Cutaneous metastases as an initial manifestation of visceral well\u2010differentiated neuroendocrine tumor: a report of four cases and a review of literature"],"prefix":"10.1111","volume":"41","author":[{"given":"Jaroslaw","family":"Jedrych","sequence":"first","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Busam","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering 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