{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:15:07Z","timestamp":1770509707018,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T00:00:00Z","timestamp":1391126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertrophic lichen planus (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>) is a variant of <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> favoring the lower extremities and showing prominent epidermal hyperplasia and hyperorthokeratosis. Contrary to dogma that eosinophils are rare in <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> and variants, we noticed that some cases of hypertrophic <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> have eosinophils in the absence of drug history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of all cases of hypertrophic <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> over 22 consecutive years was conducted. The number of eosinophils in 10 representative \u00d720\u2010fields was counted in the area of densest dermal infiltrate. Cases of classic <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> were used for comparison. Clinical parameters on all cases were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The two groups were clinically similar. The average number of eosinophils per 10 \u00d720\u2010fields in 63 cases of hypertrophic <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> was 10.5 with a range between 0 and 200. Thirteen of 63 cases (20.6%) had more than 10 eosinophils per 10 \u00d720\u2010fields. The average number of eosinophils in 17 cases of classic <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> was 1.6 (p\u2009=\u20090.016) with a range between 0 and 9 and no cases with more than 10 eosinophils (p\u2009=\u20090.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hypertrophic <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> is a distinct variant of <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> that may show variable numbers of eosinophils and should be included in the differential diagnosis of lichenoid dermatitis with eosinophils.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12275","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T16:34:54Z","timestamp":1386693294000},"page":"347-352","source":"Crossref","is-referenced-by-count":28,"title":["The significance of eosinophils in hypertrophic lichen planus"],"prefix":"10.1111","volume":"41","author":[{"given":"Ahmed","family":"Alomari","sequence":"first","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"McNiff","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"},{"name":"Department of Dermatology Yale University School of Medicine New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/2008-132-652-ID"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-838-6"},{"key":"e_1_2_5_4_1","first-page":"38","volume-title":"Skin pathology","author":"Weedon D","year":"2010"},{"key":"e_1_2_5_5_1","first-page":"17","article-title":"Lichen planus: an update and review","volume":"90","author":"Sharma A","year":"2012","journal-title":"Cutis"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1994.tb00691.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01791.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01500.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02202.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1995.tb04386.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03319.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1001\/archderm.1981.01650080073035","article-title":"Keratoacanthomas arising in hypertrophic lichen planus. 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