{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:22:30Z","timestamp":1778498550732,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T00:00:00Z","timestamp":1391040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>We report the unprecedented case of reactive eccrine syringofibroadenoma (<jats:styled-content style=\"fixed-case\">ESFA<\/jats:styled-content>) secondary to primary cutaneous amyloidosis. A 62\u2010year\u2010old woman of Asian ethnicity presented with a pruritic rash on the back of long\u2010standing duration. Physical examination revealed diffuse hyperpigmentation localized to the interscapular region; there were a multitude of hyperpigmented macules merged in a rippled pattern intermixed with scattered papules and cobblestone\u2010like areas. A punch biopsy from a papule was taken. Histopathological examination revealed a network of epithelial strands and cords hanging from the epidermis and harboring foci of ductal differentiation. Eosinophilic collections of amorphous material were found between the epithelial strands, obscuring the superficial dermis. The microscopic picture was consistent with primary cutaneous amyloidosis associated with reactive <jats:styled-content style=\"fixed-case\">ESFA<\/jats:styled-content>. Results of histochemical and immunohistochemical staining confirmed the diagnosis. We speculate that pathogenetic mechanisms intrinsic to primary cutaneous amyloidosis, in addition to unknown genetic factors, resulted in clinical changes of lichen amyloidosus associated with an abnormal hyperplastic epithelial response with histopathological features of <jats:styled-content style=\"fixed-case\">ESFA<\/jats:styled-content> rather than the common epidermal change of acanthosis and hyperkeratosis.<\/jats:p>","DOI":"10.1111\/cup.12276","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T16:21:04Z","timestamp":1386692464000},"page":"380-385","source":"Crossref","is-referenced-by-count":12,"title":["Reactive eccrine syringofibroadenomatosis secondary to primary cutaneous amyloidosis: a novel association"],"prefix":"10.1111","volume":"41","author":[{"given":"Andrea","family":"Saggini","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Rome Tor Vergata Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaddeus","family":"Mully","sequence":"additional","affiliation":[{"name":"Department of Pathology and Dermatology University of California San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,30]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03179.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181eb2f66"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00740.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70245-7"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000245977"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12104"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09311.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01083.x"},{"key":"e_1_2_4_10_1","first-page":"143","article-title":"Considerations sur les tumeurs fibro\u2010\u00e9pith\u00e9liales: le syringofibroadenome eccrine","volume":"90","author":"Mascar\u00f2 JM","year":"1963","journal-title":"Ann Dermatol Syphiligr"},{"key":"e_1_2_4_11_1","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1001\/archderm.1990.01670310107017","article-title":"Eccrine syringofibroadenoma (Mascar\u00f3). An acrosyringeal hamartoma","volume":"126","author":"Hurt MA","year":"1990","journal-title":"Arch Dermatol"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.08.032"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2000.027004164.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10612.x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1999.tb03507.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02230.x"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e318186853e"},{"key":"e_1_2_4_18_1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2340\/00015555-0547","article-title":"Sch\u00f6pf\u2010Schulz\u2010Passarge syndrome: further delineation of the phenotype and genetic considerations","volume":"88","author":"Castori M","year":"2008","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12137"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.09.735"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12160"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.09.002"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.135"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.484"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.10.042"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02545.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12276","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:40:50Z","timestamp":1696311650000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,30]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/cup.12276"],"URL":"https:\/\/doi.org\/10.1111\/cup.12276","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,30]]}}}