{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:59:44Z","timestamp":1788447584209,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous collagenous vasculopathy (<jats:styled-content style=\"fixed-case\">CCV<\/jats:styled-content>) is a rare cutaneous microangiopathy that clinically resembles generalized essential telangiectasia with only 12 cases reported to date. The perivascular fibrosis is thought to be due to production of abnormal collagen by veil cells in the outer vessel walls as a result of unknown factors. This report is of an 84\u2010year\u2010old male with progressive telangiectasia. Biopsies showed characteristic features of <jats:styled-content style=\"fixed-case\">CCV<\/jats:styled-content>. In addition, there were multiple intravascular fibrin thrombi, some organizing and associated with endothelial cell hyperplasia with recanalization reminiscent of glomeruloid bodies and simulating reactive angioendotheliomatosis (<jats:styled-content style=\"fixed-case\">RAE<\/jats:styled-content>). Histochemically and ultrastructurally fibrin was noted within the vessel walls integrating into the fibrous tissue around the vessels; however, the patient had no evidence of coagulation disorder, cryoglobulinemia or cold agglutinemia. Immunofluorescence showed fibrinogen within the vessel walls but no immunoglobulins or <jats:styled-content style=\"fixed-case\">C3<\/jats:styled-content>. As well, there were minimal inflammatory cells. This suggests pauci\u2010inflammatory injury to the endothelial cells by unknown angiogenic factors causing local intravascular fibrin thrombi with fibrin leaking and incorporating into the vessel walls, eventually leading to reparative perivascular fibrosis. This case suggests that some cases of <jats:styled-content style=\"fixed-case\">CCV<\/jats:styled-content> are related to a primary local intravascular occlusive thrombotic microangiopathy. However, the primary triggering factor causing the endothelial cell damage has yet to be elucidated.<\/jats:p>","DOI":"10.1111\/cup.12285","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T13:42:42Z","timestamp":1387374162000},"page":"386-393","source":"Crossref","is-referenced-by-count":32,"title":["Cutaneous collagenous vasculopathy associated with intravascular occlusive fibrin thrombi"],"prefix":"10.1111","volume":"41","author":[{"given":"Samih","family":"Salama","sequence":"first","affiliation":[{"name":"Department of Pathology (Dermatopathology) St. Joseph's Healthcare and McMaster University Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Chorneyko","sequence":"additional","affiliation":[{"name":"Department of Pathology Brantford General Hospital Brantford Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Belovic","sequence":"additional","affiliation":[{"name":"Department of Medicine (Dermatology) Oakville Hospital Oakville Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2000.027001040.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00930.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/11311030-000000000-00000"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.045"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2010.01.002"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01512.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2012.01936.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1989.2"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12092"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200206000-00001"},{"key":"e_1_2_5_12_1","first-page":"1007","volume-title":"Lever's Histopathology of the Skin","author":"Calonje E","year":"2009"},{"key":"e_1_2_5_13_1","first-page":"888","volume-title":"Skin Pathology","author":"Weedon D","year":"2010"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02568.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1999.tb01830.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1983.tb04620.x"},{"key":"e_1_2_5_17_1","unstructured":"HenrichsJ.BarthelsM NeumannCH MarghescuS. 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