{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:15:44Z","timestamp":1779286544956,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T00:00:00Z","timestamp":1391644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>We present a rare case of Merkel cell carcinoma (<jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content>) with heterologous differentiation. The patient was an 86\u2010year\u2010old female patient with <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content> who presented with a forearm skin tumor and left axillary lymph node swelling. Histopathologically, the malignant components of the primary and metastatic lesions showed the intermingled features of triphasic phenotype differentiation, which had distinct cell populations; <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content>, sweat gland carcinoma (<jats:styled-content style=\"fixed-case\">SGC<\/jats:styled-content>) and malignant poorly differentiated spindle cells with myogenic differentiation were immunohistochemically showed. Moreover, an electron microscopic observation of the tumor cells revealed intracytoplasmic canaliculi and junctional structures that indicated ductal differentiation. To our knowledge, this is the first case of <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content> admixed with <jats:styled-content style=\"fixed-case\">SGC<\/jats:styled-content> and sarcomatous components in both the primary and metastatic lesions. An immunohistochemical study, using several stem cell markers, indicated that the <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content> arose from pluripotent epidermal stem cells.<\/jats:p>","DOI":"10.1111\/cup.12289","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T17:30:51Z","timestamp":1387906251000},"page":"469-474","source":"Crossref","is-referenced-by-count":9,"title":["Triphasic differentiations of Merkel cell carcinoma in primary and metastatic lesions"],"prefix":"10.1111","volume":"41","author":[{"given":"Shinichi","family":"Koba","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Misago","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Nagase","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Inoue","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, Faculty of Medicine Saga University Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehisa","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, Faculty of Medicine Saga University Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Narisawa","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,6]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1972.01620040075020"},{"key":"e_1_2_4_3_1","first-page":"162","article-title":"Divergent differentiation in endocrine and nonendocrine tumors of the skin","volume":"17","author":"Foschini MP","year":"2000","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2010.02.002"},{"key":"e_1_2_4_5_1","first-page":"427","article-title":"Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies","volume":"140","author":"Moll R","year":"1992","journal-title":"Am J Pathol"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152586"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806526105"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181aa30a5"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24790"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25136"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24510"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.09.011"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.25904"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2002.291010.x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000288"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199712000-00011"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00896.x"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.0229"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/01913120590951284"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01794.x"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10227-005-0024-4"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200102000-00008"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00917.x"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03791.x"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2011.01.011"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12091"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12289","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:45:09Z","timestamp":1696401909000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,6]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/cup.12289"],"URL":"https:\/\/doi.org\/10.1111\/cup.12289","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,6]]}}}