{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:30:05Z","timestamp":1784165405829,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A few series addressing the cutaneous side effects related to imatinib in the skin have been published, but only one described scarce histopathologic information in seven patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize these lesions and compare the number of melanocytes between hypopigmented lesions and normal appearing skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrieved clinical data of the patients and performed 24 skin biopsies (13 from hypopigmented skin and 11 from normal\u2010appearing skin) within a cohort of 41 patients with chronic myeloid leukemia treated with imatinib. We classified the biopsies into three patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 45% of patients presented with periocular hypopigmentation. Perifollicular fibrosis was observed in hypopigmented skin biopsies (76.9%) and in normal\u2010appearing skin (45.5%). Epidermal melanin, as determined with Masson\u2010Fontana staining, and melanocyte number, as evaluated with <jats:styled-content style=\"fixed-case\">MiTF<\/jats:styled-content>, Melan A and c\u2010kit immunostains, were lower in hypopigmented skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Histopathologic study of hypopigmented macules demonstrates the presence of melanin with a statistically significant decrease in the number of melanocytes. Therefore, these findings differ from vitiligo, as melanocytes are present. Three histopathological patterns may be found, namely (a) perifollicular fibrosis, (b) lichen planopilaris\u2010like and (c) apparently normal skin. One of the most striking histopathologic finding consisted of the presence of perifollicular fibrosis in both hypopigmented lesions and apparently normal skin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12298","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T12:32:12Z","timestamp":1390912332000},"page":"417-426","source":"Crossref","is-referenced-by-count":19,"title":["Hypopigmented macules secondary to imatinib for the treatment of chronic myeloid leukemia: a histopathologic and immunohistochemical study"],"prefix":"10.1111","volume":"41","author":[{"given":"Mar","family":"Llamas\u2010Velasco","sequence":"first","affiliation":[{"name":"Department of Dermatology, Instituto de Investigaci\u00f3n Sanitaria de La Princesa (IP) Hospital Universitario de la Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Fraga","sequence":"additional","affiliation":[{"name":"Department of Pathology, Instituto de Investigaci\u00f3n Sanitaria de La Princesa (IP) Hospital Universitario de la Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Kutzner","sequence":"additional","affiliation":[{"name":"Department of Dermatopathologie Dermatopathologie Friedrichshafen Friedrichshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luis","family":"Steegmann","sequence":"additional","affiliation":[{"name":"Department of Haematology, Instituto de Investigaci\u00f3n Sanitaria de La Princesa (IP) Hospital Universitario de la Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaro","family":"Garc\u00eda\u2010Diez","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Instituto de Investigaci\u00f3n Sanitaria de La Princesa (IP) Hospital Universitario de la Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Requena","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fundaci\u00f3n Jim\u00e9nez Diaz Madrid 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