{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:00:17Z","timestamp":1785682817125,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Importance<\/jats:title><jats:p>Extramammary Paget disease (<jats:styled-content style=\"fixed-case\">EMPD<\/jats:styled-content>) is an uncommon tumor that presents in apocrine\u2010rich skin as an irregular, pruritic plaque. Histopathologically, <jats:styled-content style=\"fixed-case\">EMPD<\/jats:styled-content> consists of an intraepidermal proliferation of atypical epithelioid cells. Rarely, the tumor cells contain intracytoplasmic melanin pigment, and the lesion clinically and histopathologically can mimic a melanocytic proliferation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Observations<\/jats:title><jats:p>A 51\u2010year\u2010old female with a history of breast carcinoma presented with a pigmented patch on her right thigh of 6\u2009months duration. The clinical impression was an atypical melanocytic nevus. Histopathologic examination revealed an intraepidermal proliferation of epithelioid cells along the dermal\u2013epidermal junction with pagetoid migration. The tumor cells exhibited increased cytoplasm containing conspicuous melanin pigment and enlarged oval\u2010irregular nuclei. Immunohistochemical studies showed the tumor cells to be strongly and diffusely positive for cytokeratin 8\/18, cytokeratin 7 and p63; focally and weakly positive for epithelial membrane antigen (<jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content>), but negative for cytokeratin 5\/6, Cam5.2, carcinoembryonic antigen (<jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>), human melanoma black 45 (<jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>\u201045), tyrosinase and Sox\u201010, supporting the diagnosis of pigmented <jats:styled-content style=\"fixed-case\">EMPD<\/jats:styled-content>. The lesion was subsequently excised, and the patient is free of disease after 24\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We present this unusual case of pigmented <jats:styled-content style=\"fixed-case\">EMPD<\/jats:styled-content> arising on the thigh to draw attention to the entity and to underscore the potentially misleading clinical, histopathologic and immunophenotypic features that mimic other cutaneous intraepidermal lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12333","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T15:13:06Z","timestamp":1394637186000},"page":"529-535","source":"Crossref","is-referenced-by-count":21,"title":["Pigmented extramammary Paget disease of the thigh mimicking a melanocytic tumor: report of a case and review of the literature"],"prefix":"10.1111","volume":"41","author":[{"given":"Maria M.","family":"De la Garza Bravo","sequence":"first","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Curry","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center Houston TX USA"},{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Torres\u2010Cabala","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center Houston TX USA"},{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doina 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