{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:07:05Z","timestamp":1792084025234,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T00:00:00Z","timestamp":1404864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>Phacomatosis pigmentokeratotica (<jats:styled-content style=\"fixed-case\">PPK<\/jats:styled-content>) is characterized by the co\u2010existence of epidermal nevi and large segmental speckled lentiginous nevi of the papulosa type. <jats:styled-content style=\"fixed-case\">PPK<\/jats:styled-content>, previously explained as \u2018twin spot\u2019 mosaicism due to the postzygotic crossing\u2010over of two homozygous recessive mutations, has recently been shown to derive from one postzygotic activating <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> mutation. Epidermal nevi, including those in <jats:styled-content style=\"fixed-case\">PPK<\/jats:styled-content>, are known to give rise to neoplasms such as trichoblastoma and basal cell carcinoma. Within speckled lentiginous nevi, Spitz nevi and melanoma have been well documented. We report a case of <jats:styled-content style=\"fixed-case\">PPK<\/jats:styled-content> with a combined melanocytic and adnexal neoplasm presenting where the nevi conjoined. Using next\u2010generation sequencing techniques, we were able to identify the same <jats:styled-content style=\"fixed-case\">HRAS G13R<\/jats:styled-content> mutation within both components of the tumor, and to show the absence of additional mutated modifier genes in a panel of 300 cancer\u2010related genes. Given the genetic findings in this rare tumor\u2010type, we suggest that this case may be used as a model for understanding the development of biphenotypic neoplasia or intratumoral heterogeneity in some cases.<\/jats:p>","DOI":"10.1111\/cup.12339","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T19:30:28Z","timestamp":1394825428000},"page":"663-671","source":"Crossref","is-referenced-by-count":15,"title":["Combined melanocytic and sweat gland neoplasm: cell subsets harbor an identical <scp>HRAS<\/scp> mutation in phacomatosis pigmentokeratotica"],"prefix":"10.1111","volume":"41","author":[{"given":"Janet Y.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Medicine, Dermatology Service Memorial Sloan\u2010Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashfaq","family":"Marghoob","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dermatology Service Memorial Sloan\u2010Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh K.","family":"Bhanot","sequence":"additional","affiliation":[{"name":"Pathology Core Facility Memorial Sloan\u2010Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer P.","family":"Toyohara","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa P.","family":"Pulitzer","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2005.22110.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.3.333"},{"key":"e_1_2_6_4_1","first-page":"190","article-title":"Phacomatosis pigmentokeratotica: another epidermal nevus syndrome and a distinctive type of twin spotting","volume":"10","author":"Boente MC","year":"2000","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01407.x"},{"key":"e_1_2_6_6_1","first-page":"293","article-title":"Cutaneous basosquamous carcinoma. 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