{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:39:02Z","timestamp":1776922742796,"version":"3.51.2"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T00:00:00Z","timestamp":1413590400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>CHILD syndrome is an acronym signifying <jats:italic>congenital hemidysplasia with ichthyosiform nevus and limb defects<\/jats:italic>. A 27\u2010year\u2010old woman presented with chronic verrucous and hyperkeratotic skin lesions involving the left genital area, left hand and left foot since childhood. The histopathologic findings were consistent with verruciform xanthoma. In correlation with the clinical picture of a linear lesion, the diagnosis of CHILD nevus was made. Subsequent genetic analysis identified a germline c.324C&gt;T (p.A105V) <jats:italic>NSDHL<\/jats:italic> mutation and confirmed a diagnosis of CHILD syndrome. This syndrome can be associated with only minimal clinical symptoms. The anatomical distribution of the lesions, a static clinical course and the typical histopathologic features of a CHILD nevus can serve as the clue to a diagnosis of CHILD syndrome in such cases.<\/jats:p>","DOI":"10.1111\/cup.12377","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T12:43:15Z","timestamp":1407242595000},"page":"787-790","source":"Crossref","is-referenced-by-count":21,"title":["<scp>CHILD<\/scp> syndrome with mild skin lesions: histopathologic clues for the diagnosis"],"prefix":"10.1111","volume":"41","author":[{"given":"Susanne","family":"Gantner","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Regensburg  Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"R\u00fctten","sequence":"additional","affiliation":[{"name":"Dermatopathology Friedrichshafen  Friedrichshafen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Requena","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Gassenmaier","sequence":"additional","affiliation":[{"name":"Dermatology  Passau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Landthaler","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Regensburg  Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Hafner","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Regensburg  Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,18]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00442399"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70285-P"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246548"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2006.00470.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03483.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.3.348"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000214)90:4<339::AID-AJMG15>3.0.CO;2-5"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.024448"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20248"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01276.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086448"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.113680"},{"key":"e_1_2_4_14_1","first-page":"105","article-title":"CHILD syndrome in a mother and daughter","volume":"41","author":"Happle R","year":"1990","journal-title":"Hautarzt"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000287253"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.189"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-9-33"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12377","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:24:48Z","timestamp":1696238688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/cup.12377"],"URL":"https:\/\/doi.org\/10.1111\/cup.12377","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}