{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:18:08Z","timestamp":1766269088393,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T00:00:00Z","timestamp":1413590400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Primary cutaneous follicle center lymphoma (PCFCL<\/jats:styled-content>) is the most frequent cutaneous B\u2010cell lymphoma. A 62\u2010year\u2010old man presented with a solitary indolent subcutaneous nodule for 3 years duration, without other abnormalities. Histological examination showed lymphoproliferation with a nodular growth pattern characterized by fibrous collagen bands surrounding nodules. The nodules were composed of medium\u2010sized centrocytes admixed with many large multilobulated and lacunar cells without eosinophils or granulomatous aspect. Hodgkin\u2010like cells were CD30<\/jats:styled-content>+, CD15<\/jats:styled-content>+, PAX5<\/jats:styled-content>+, OCT2<\/jats:styled-content>+, BOB1<\/jats:styled-content>+, MUM1<\/jats:styled-content>+, Ki67+, Bcl6+ and focally CD20<\/jats:styled-content>+ and EMA<\/jats:styled-content>\u2212, CD79a<\/jats:styled-content>\u2212, Bcl2\u2212 and CD10<\/jats:styled-content>\u2212. The medium\u2010sized cells were CD20<\/jats:styled-content>+, CD79a<\/jats:styled-content>+, Bcl2+, Bcl6+ and CD10<\/jats:styled-content>+, enmeshed in a network of CD21<\/jats:styled-content>\u2010positive follicular dendritic cells. Epstein\u2010Barr virus detection was negative. Interphase fluorescence in situ hybridization showed the absence of BCL2<\/jats:styled-content> or BCL6<\/jats:styled-content> rearrangement. In such a case, the presence of Hodgkin\u2010like cells intermixed with the tumor population may result in a pitfall diagnosis of classical Hodgkin lymphoma (CHL<\/jats:styled-content>). Differential diagnoses to be ruled out are secondary or primary skin localization of rather CHL<\/jats:styled-content>, or systemic follicular lymphoma. Several clinical, radiological, histological, immunohistochemical and molecular arguments indicated the diagnosis of PCFCL<\/jats:styled-content>. To our knowledge, this is the first report of PCFCL<\/jats:styled-content> with Hodgkin\u2010like cells.<\/jats:p>","DOI":"10.1111\/cup.12379","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T13:47:24Z","timestamp":1407246444000},"page":"797-801","source":"Crossref","is-referenced-by-count":19,"title":["Primary cutaneous follicle center lymphoma with Hodgkin and Reed\u2010Sternberg\u2010like cells: a new histopathologic variant"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4254-5351","authenticated-orcid":false,"given":"Dilly","family":"Marie","sequence":"first","affiliation":[{"name":"Department of Pathology University Hospital of Bordeaux, University of Bordeaux EA2406 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben\u2010Rejeb","family":"Houda","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Bordeaux, University of Bordeaux EA2406 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vergier","family":"B\u00e9atrice","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Bordeaux, University of Bordeaux EA2406 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feldis","family":"Matthieu","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Bordeaux, University of Bordeaux EA2406 Bordeaux France"},{"name":"Department of Radiology University Hospital of Bordeaux Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toty","family":"Louis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Centre m\u00e9dico\u2010chirurgical de l'Atlantique Puilboreau La Rochelle France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nohra","family":"Olivier","sequence":"additional","affiliation":[{"name":"Department of Pathology Centre de Pathologie Atlantique La Rochelle France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beylot\u2010Barry","family":"Marie","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Bordeaux, University of Bordeaux EA2406 Bordeaux France"},{"name":"Department of Dermatology University Hospital of Bordeaux, University of Bordeaux EA2406 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gros","family":"Audrey","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Bordeaux, University of Bordeaux EA2406 Bordeaux France"},{"name":"Department of Molecular Biology University Hospital of Bordeaux, University of Bordeaux EA2406 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merlio","family":"Jean\u2010Philippe","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Bordeaux, University of Bordeaux EA2406 Bordeaux France"},{"name":"Department of Molecular Biology University Hospital of Bordeaux, University of Bordeaux EA2406 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parrens","family":"Marie","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Bordeaux, University of Bordeaux EA2406 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,18]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"227","volume-title":"WHO classification of tumors of haematopoietic and lymphoid tissues","author":"World Health Organization","year":"2008"},{"key":"e_1_2_4_3_1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1182\/blood.V95.3.1023.003k07_1023_1031","article-title":"Hodgkin and Reed\u2010Sternberg\u2010like cells in B\u2010cell chronic lymphocytic leukemia represent the outgrowth of single 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