{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:44Z","timestamp":1787014064699,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Acantholysis in pemphigus vulgaris (\n                      <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>\n                      ) and pemphigus foliaceus (\n                      <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>\n                      ) occurs predominantly in the suprabasal area and the granular layer, respectively. However, acantholysis can occasionally be observed in unusual locations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively studied the acantholysis locations in 35\n                      <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>\n                      and 27\n                      <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>\n                      cases, and analyzed them using the index value of Desmoglein (Dsg) 1 and Dsg3 by enzyme\u2010linked immunosorbent assay, clinical data, and inflammatory cells. We also analyzed the relationship between clinical subtype and various parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In\n                      <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>\n                      , acantholysis was noted in the suprabasal area in 3 cases, in the lower half of the epidermis in 19 cases, and throughout the epidermis in 13 cases. In\n                      <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>\n                      , acantholysis was observed in the granular layer in 6 cases, in the upper half of the epidermis in 14 cases, and throughout the epidermis in 7 cases. Mean index value of Dsg1 in\n                      <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>\n                      patients with acantholysis throughout the epidermis was 2\u2010fold higher than other\n                      <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>\n                      patients. Neutrophils tended to infiltrate the dermis and epidermis more in\n                      <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>\n                      than in\n                      <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Higher Dsg1 index values seem to correlate with acantholysis in the upper part of the epidermis in\n                      <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>\n                      . Neutrophils may play some role in unusual acantholysis locations in\n                      <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cup.12384","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T07:39:55Z","timestamp":1412062795000},"page":"880-889","source":"Crossref","is-referenced-by-count":20,"title":["Locations of acantholysis in pemphigus vulgaris and pemphigus foliaceus"],"prefix":"10.1111","volume":"41","author":[{"given":"Chika","family":"Ohata","sequence":"first","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norito","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minao","family":"Furumura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02752.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70183-0"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5252"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.01.106"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10827.x"},{"key":"e_1_2_5_7_1","first-page":"235","volume-title":"Lever's histopathology of the skin","author":"Wu H","year":"2009"},{"key":"e_1_2_5_8_1","first-page":"586","volume-title":"Fitzpatrick's dermatology in general medicine","author":"Payne AS","year":"2012"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04981.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02533.x"},{"key":"e_1_2_5_11_1","first-page":"161","article-title":"Clinical features and course of pemphigus in Thai patients","volume":"29","author":"Kulthanan K","year":"2011","journal-title":"Asian Pac J Allergy Immunol."},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04362.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1979.tb03570.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2340\/0001555561535542","article-title":"Treatment of Darier's disease with an oral aromatic retinoid (Ro 10\u20109359): a clinical and light and electron microscopic study","volume":"61","author":"Lauharanta J","year":"1981","journal-title":"Acta Derm Venereol."},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2002.290110.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2011.1352"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12384","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T23:33:03Z","timestamp":1696203183000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/cup.12384"],"URL":"https:\/\/doi.org\/10.1111\/cup.12384","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}