{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:31:33Z","timestamp":1788517893471,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T00:00:00Z","timestamp":1415664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>Ductal carcinoma <jats:italic>in situ<\/jats:italic> (<jats:styled-content style=\"fixed-case\">DCIS<\/jats:styled-content>) in the mammary glands consists of a proliferation of ductal luminal cells with preserved polarity but lacking the marked intercellular cohesion of hyperplastic cells. We report two cases of <jats:styled-content style=\"fixed-case\">DCIS<\/jats:styled-content> arising in the apocrine glandular structures of a nevus sebaceus (<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>). The first patient was a 44\u2010year\u2010old woman with a ductal neoplasm composed of multilayered ductal elements with a monomorphous cellularity and a polar orientation of nuclei. The neoplastic cells were positive for Cm5.2 and <jats:styled-content style=\"fixed-case\">CK7<\/jats:styled-content>. The second patient was a 67\u2010year\u2010old woman with phacomatosis pigmentokeratotica. A skin biopsy of an erythematous plaque within her <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content> showed an epithelioid monomorphous tumor with eosinophilic and slightly granular cytoplasm. Slight nuclear pleomorphism with some hyperchromatic nuclei was seen. The tumor cells were positive for <jats:styled-content style=\"fixed-case\">CK7<\/jats:styled-content> and gross cystic disease fluid protein\u201015. Actin showed a preserved layer of myoepithelial cells in both cases. Our cases are noteworthy, as secondary malignancies or multiple tumors arising in <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content> are rare, and the presence of multiple neoplasms in phacomatosis pigmentokeratotica is even rarer. Moreover, these tumors expand the spectrum of secondary malignant neoplasms arising in <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>, as they closely resemble mammary <jats:styled-content style=\"fixed-case\">DCIS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cup.12394","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T05:47:17Z","timestamp":1412920037000},"page":"944-949","source":"Crossref","is-referenced-by-count":12,"title":["Apocrine intraductal carcinoma <i>in situ<\/i> in nevus sebaceus: two case reports"],"prefix":"10.1111","volume":"41","author":[{"given":"Mar","family":"Llamas\u2010Velasco","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Infanta Cristina  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Requena","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fundaci\u00f3n Jim\u00e9nez Diaz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Podda","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Klinikum Darmstadt  Darmstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Weidenthaler\u2010Barth","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Universit\u00e4ts\u2010Hautklinik  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"R\u00fctten","sequence":"additional","affiliation":[{"name":"Dermatopathologie Bodensee Friedrichshafen  Friedrichshafen 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