{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:03:50Z","timestamp":1792008230466,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T00:00:00Z","timestamp":1415664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"\n Primary cutaneous gamma\u2010delta (\u03b3\u03b4) T\u2010cell lymphoma is an extremely rare and aggressive variant of cutaneous lymphoma. Central nervous system (\n CNS<\/jats:styled-content>\n ) involvement, a rare finding, and hemophagocytic syndrome are two complications that are commonly fatal. We describe a 58\u2010year\u2010old patient presenting with skin plaque who subsequently developed subcutaneous nodules diagnosed as cutaneous T\u2010cell lymphoma (\n CTCL<\/jats:styled-content>\n ), clinically resembling \u2018mycosis fungoides\u2019. The patient was treated with repeat topical radiation therapies but had frequent relapsed disease. Approximately 4.5 years after, the patient presented with third and sixth cranial nerve palsies and was found to have\n CNS<\/jats:styled-content>\n involvement by lymphoma per positron emission tomography\u2014computed tomography (\n PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n ) and a biopsy of foramen magnum. Phenotypically, the tumor cells were\n CD3<\/jats:styled-content>\n (+)\/\n CD4<\/jats:styled-content>\n (\u2212)\/\n CD8<\/jats:styled-content>\n (\u2212)\/\n CD7<\/jats:styled-content>\n (+)\/\n CD5<\/jats:styled-content>\n (\u2212)\/\n CD30<\/jats:styled-content>\n (\u2212)\/\n TCR\u03b1\u03b2<\/jats:styled-content>\n (\u2212)\/\n TCR\u03b3\u03b4<\/jats:styled-content>\n (+). Despite aggressive strategies taken, the patient expired 3 months after the diagnosis of the\n CNS<\/jats:styled-content>\n lesion. A retrospective investigation proved the original\n CTCL<\/jats:styled-content>\n to be \u03b3\u03b4 T\u2010cell in origin, confirming an indolent cutaneous \u03b3\u03b4 T\u2010cell lymphoma with eventual\n CNS<\/jats:styled-content>\n manifestation. We present this case to draw attention to the entity, which can occasionally present with misleading histopathologic and clinical features. In addition, we provide a review of the literature to summarize clinical and pathologic features of the reported similar cases.\n <\/jats:p>","DOI":"10.1111\/cup.12395","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T05:38:29Z","timestamp":1412746709000},"page":"936-943","source":"Crossref","is-referenced-by-count":20,"title":["Cutaneous gamma\u2010delta T\u2010cell lymphoma with central nervous system involvement: report of a rarity with review of literature"],"prefix":"10.1111","volume":"41","author":[{"given":"Lacey","family":"Harrington","sequence":"first","affiliation":[{"name":"Department of Pathology University of South Florida Morsani College of Medicine Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubomir","family":"Sokol","sequence":"additional","affiliation":[{"name":"Department of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Holdener","sequence":"additional","affiliation":[{"name":"Department of Pathology University of South Florida Morsani College of Medicine Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haipeng","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Hematopathology and Laboratory Medicine H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology and Laboratory Medicine H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,11]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.729831"},{"key":"e_1_2_4_3_1","first-page":"302","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Gaulard P","year":"2008"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31826a5038"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1460"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2011.23.S1.S100"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1597"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPQGVLTZQ77VFF"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.317"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12470953"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2258-7"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3182624e98"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.618234"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318275d1a2"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00931.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12091"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.724533"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880133"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2012.05.006"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12395","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:32:12Z","timestamp":1696314732000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,11]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/cup.12395"],"URL":"https:\/\/doi.org\/10.1111\/cup.12395","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,11]]}}}