{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:52:42Z","timestamp":1779396762895,"version":"3.53.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T00:00:00Z","timestamp":1418601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertrophic discoid lupus erythematosus (<jats:styled-content style=\"fixed-case\">HDLE<\/jats:styled-content>), a rare variant of lupus skin disease, is difficult to distinguish from squamous neoplasms and certain dermatoses microscopically. Recently, recognition of the pathogenetic significance of plasmacytoid dendritic cells (<jats:styled-content style=\"fixed-case\">PDCS<\/jats:styled-content>) in cutaneous lupus erythematosus (LE) and of their patterns of distribution in different manifestations of the disease prompted us to study their diagnostic value in the context of <jats:styled-content style=\"fixed-case\">HDLE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using immunohistochemistry (<jats:styled-content style=\"fixed-case\">CD123<\/jats:styled-content>) to label the cells, we examined their quantities and patterns of distribution in 27 tissue samples of <jats:styled-content style=\"fixed-case\">HDLE<\/jats:styled-content> from nine patients compared with 39 inflammatory and neoplastic control samples from 36 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using three parameters pertaining to PDCs: (i) their representation of 10% or more of the inflammatory infiltrate, (ii) their arrangement in clusters of 10 cells or more and (iii) their presence at the dermoepidermal junction, we found them to have significant diagnostic value, with accuracies of 77%, 74% and 71%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study supports the careful descriptive observations of previous authors in the field. It also lends validity to the diagnostic step of mapping, immunohistochemically, the density and distribution of PDCs in suspected cases of <jats:styled-content style=\"fixed-case\">HDLE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12416","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T08:58:47Z","timestamp":1415091527000},"page":"32-38","source":"Crossref","is-referenced-by-count":36,"title":["Plasmacytoid dendritic cells in hypertrophic discoid lupus erythematosus: an objective evaluation of their diagnostic value"],"prefix":"10.1111","volume":"42","author":[{"given":"Noreen M.","family":"Walsh","sequence":"first","affiliation":[{"name":"Department of Pathology Capital District Health Authority and Dalhousie University  Halifax NS Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Pathology Capital District Health Authority and Dalhousie University  Halifax NS Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Hanly","sequence":"additional","affiliation":[{"name":"Department of Medicine Capital District Health Authority and Dalhousie University  Halifax NS Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Medicine Capital District Health Authority and Dalhousie University  Halifax NS Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bosisio","sequence":"additional","affiliation":[{"name":"Research Unit Dermatopathology, Department of Dermatology Medical University of Graz  Graz Austria"},{"name":"Department of Surgical Sciences Milano\u2010Bicocca University  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Garcias\u2010Ladaria","sequence":"additional","affiliation":[{"name":"Research Unit Dermatopathology, Department of Dermatology Medical University of Graz  Graz Austria"},{"name":"Department of Dermatology Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Cerroni","sequence":"additional","affiliation":[{"name":"Research Unit Dermatopathology, Department of Dermatology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,15]]},"reference":[{"issue":"2","key":"e_1_2_6_2_1","first-page":"AB67","article-title":"Hypertrophic discoid lupus erythematosus: a rare variant of DLE","volume":"56","author":"Hundley J","year":"2007","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1995.tb00167.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0241-CR"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1978.tb01936.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2003.00082.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61689-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01587.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01779.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12105"},{"key":"e_1_2_6_11_1","first-page":"107","volume-title":"Histologic diagnosis of inflammatory skin diseases. An algorithmic method based on pattern analysis","author":"Ackerman AB","year":"1997"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38301"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.23.12551"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5405.1183"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38298"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12416","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:29:36Z","timestamp":1696336176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,15]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/cup.12416"],"URL":"https:\/\/doi.org\/10.1111\/cup.12416","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,15]]}}}