{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:20:31Z","timestamp":1766269231026},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T00:00:00Z","timestamp":1417996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>We present the case of an 84\u2010year\u2010old patient with a cutaneous <jats:styled-content style=\"fixed-case\">CD56<\/jats:styled-content> positive cytotoxic T\u2010cell lymphoma associated with substantial pseudocarcinomatous hyperplasia mimicking squamous cell carcinoma (SCC). The patient presented with a 7\u2010month history of several progressive, ulcerated plaques on his right forearm. An initial biopsy showed changes consistent with a diagnosis of SCC for which the patient underwent surgical treatment. Several months later, the patient developed recurrent ulcerated plaques on the right forearm of which several biopsies were performed. The biopsies repeatedly showed marked pseudocarcinomatous hyperplasia resembling SCC. Deeper punch biopsies, however, showed a dense superficial and deep infiltrate of markedly atypical lymphocytes. Immunohistochemical analysis revealed strong positive staining for <jats:styled-content style=\"fixed-case\">CD3<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD56<\/jats:styled-content> with negative stains for <jats:styled-content style=\"fixed-case\">CD30<\/jats:styled-content> and Epstein\u2010Barr virus\u2010encoded small non\u2010polyadenylated <jats:styled-content style=\"fixed-case\">RNAs<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">EBER<\/jats:styled-content>). Staining for beta <jats:styled-content style=\"fixed-case\">F1<\/jats:styled-content> and gamma\u2010delta T\u2010cell receptor (\u03b3\u03b4 <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>) were both negative. This constellation was most consistent with a diagnosis of cutaneous peripheral T\u2010cell lymphoma, unspecified in association with marked pseudocarcinomatous hyperplasia. Our case adds cutaneous peripheral T\u2010cell lymphoma, unspecified to the list of conditions associated with pseudocarcinomatous hyperplasia (<jats:styled-content style=\"fixed-case\">PCH<\/jats:styled-content>) and illustrates once again the potential pitfalls of distinguishing marked pseudocarcinomatous hyperplasia from SCC.<\/jats:p>","DOI":"10.1111\/cup.12421","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T10:20:22Z","timestamp":1415182822000},"page":"194-198","source":"Crossref","is-referenced-by-count":6,"title":["Pseudocarcinomatous hyperplasia mimicking squamous cell carcinoma in a case of <scp>CD56<\/scp>\u2010positive cytotoxic T\u2010cell lymphoma"],"prefix":"10.1111","volume":"42","author":[{"given":"David","family":"Ginsberg","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical College of Wisconsin  Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical College of Wisconsin  Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical College of Wisconsin  Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A.","family":"Plaza","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical College of Wisconsin  Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan M.","family":"Schieke","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical College of Wisconsin  Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,8]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181fcfb47"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.110875"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31818779de"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03013.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02703.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181648d6d"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2009.1.523"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-1960"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1993.tb00643.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689690401200410"},{"key":"e_1_2_4_13_1","first-page":"239","article-title":"Is there a positive relationship between CD30\u2010positive lymphoproliferative disorders and epidermal proliferation?","volume":"44","author":"Cespedes YP","year":"2000","journal-title":"J Cutan Pathol"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2007.02477.x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.00204.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31826a5038"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822067d1"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12421","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12421","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.12421","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T10:28:06Z","timestamp":1693304886000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,8]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/cup.12421"],"URL":"https:\/\/doi.org\/10.1111\/cup.12421","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,8]]}}}