{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:40:37Z","timestamp":1785552037746,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T00:00:00Z","timestamp":1417996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The recognition of folliculotropic mycosis fungoides (<jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content>) may pose diagnostic challenges, owing to the variety of histopathological findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>In this study, our aim is to describe the broad spectrum of the histopathological patterns in a total of 86 biopsies from 38 patients with <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content>, together with the clinical features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most frequent histopathologic pattern was the folliculocentric\/folliculotropic pattern, with or without follicular mucinosis. Keratin\u2010filled cysts and comedones were the second most common pattern in the biopsies. Other less common findings included widening of the hair follicle orifis with keratotic plugging, reminiscent of keratosis pilaris, granuloma formation, eosinophilic or suppurative folliculitis and basaloid folliculolymphoid hyperplasia. Coexisting syringotropism was present in some biopsies. The <jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content> : <jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content> ratio was at least 4 : 1 or more in most biopsies. Grouped follicular papules and patch\/plaque lesions with follicular prominence were the most frequent clinical findings. Folliculocentric lesions such as milia, cysts and acneiform lesions, alopecia, loss of hair or eyebrows were also seen. In 6 out of 38 (15.8%) patients, transformation to large\u2010cell lymphoma was observed during the follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The awareness and the identification of the various histopathological presentations of <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> by pathologists, as well as by clinicians, are imperative to prevent diagnostic errors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12423","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T09:22:49Z","timestamp":1415265769000},"page":"22-31","source":"Crossref","is-referenced-by-count":39,"title":["The clinical features and histopathologic patterns of folliculotropic mycosis fungoides in a series of 38 cases"],"prefix":"10.1111","volume":"42","author":[{"given":"Cuyan","family":"Demirkesen","sequence":"first","affiliation":[{"name":"Department of Pathology Cerrahpa\u015fa Medical Faculty, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galip","family":"Esirgen","sequence":"additional","affiliation":[{"name":"Department of Pathology Cerrahpa\u015fa Medical Faculty, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burhan","family":"Engin","sequence":"additional","affiliation":[{"name":"Departments of Dermatology Cerrahpa\u015fa Medical Faculty, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Songur","sequence":"additional","affiliation":[{"name":"Departments of Dermatology Cerrahpa\u015fa Medical Faculty, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oya","family":"O\u011fuz","sequence":"additional","affiliation":[{"name":"Departments of Dermatology Cerrahpa\u015fa Medical Faculty, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.2.191"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3180439bdc"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.6.738"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1476"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.101"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2012.01965.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.281006.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2000.027008406.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02984.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.014"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107741"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304060-00006"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03752.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07672.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12423","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:29:37Z","timestamp":1696336177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,8]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/cup.12423"],"URL":"https:\/\/doi.org\/10.1111\/cup.12423","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,8]]}}}