{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:27:47Z","timestamp":1766269667559},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T00:00:00Z","timestamp":1422921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>Chronic lymphocytic leukemia (<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SLL<\/jats:styled-content>) is the most common leukemia in the western world and its cutaneous dissemination a very uncommon phenomenon. Lymphomatoid papulosis (<jats:styled-content style=\"fixed-case\">LyP<\/jats:styled-content>) is a <jats:styled-content style=\"fixed-case\">CD30<\/jats:styled-content>+ lymphoproliferative disorder characterized by chronic, recurrent and self healing skin lesions. Up to 20% of patients with <jats:styled-content style=\"fixed-case\">LyP<\/jats:styled-content> have a coexistent lymphoma. While the association between the two entities has been reported, their coexistence has never been documented. We describe a 74\u2010year\u2010old man with known <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> and thrombocytopenia who presented with a 2\u2009year history of recurrent nodules and plaques to both arms and legs that resolved within 4\u20136\u2009weeks after administration of rituximab and bendamustin for his <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> treatment. His biopsies showed an atypical lymphoid infiltrate, composed of large and pleomorphic cells with a nodular and interstitial pattern in a background of eosinophils. Immunohistochemical staining revealed a pattern of two separate yet coexisting neoplastic processes; a large <jats:styled-content style=\"fixed-case\">CD30<\/jats:styled-content> positive T\u2010cell lymphoproliferative disorder, while the other one was diagnostic of a neoplastic B\u2010cell process (leukemia cutis). A diagnosis of coexistent <jats:styled-content style=\"fixed-case\">LyP<\/jats:styled-content> and cutaneous involvement by <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SLL<\/jats:styled-content> was rendered. The simultaneous presence of both disorders can be a pitfall in the differential diagnosis of large cell lymphomas, such as Richter's transformation of <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SLL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cup.12435","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T09:17:11Z","timestamp":1415611031000},"page":"276-284","source":"Crossref","is-referenced-by-count":6,"title":["A unique case of concurrent chronic lymphocytic leukemia\/small lymphocytic lymphoma and lymphomatoid papulosis in the same biopsy"],"prefix":"10.1111","volume":"42","author":[{"given":"J.","family":"Hibler","sequence":"first","affiliation":[{"name":"O'Bleness Hospital Ohio University  Athens OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea L.","family":"Salavaggione","sequence":"additional","affiliation":[{"name":"Department of 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