{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:12:30Z","timestamp":1785683550202,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T00:00:00Z","timestamp":1418256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Background<\/jats:title>Pseudolymphomatous folliculitis is a lymphoid proliferation that clinically and histopathologically mimics primary cutaneous extranodal marginal zone lymphoma of mucosa\u2010associated lymphoid tissue (MALT<\/jats:styled-content> lymphoma). In this study, we assessed the diagnostic value of three immunohistochemical markers, programmed death\u20101 (PD<\/jats:styled-content>\u20101), CD1a<\/jats:styled-content> and S100<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We evaluated 25 cases of cutaneous lymphoid proliferations with established diagnoses, including 9 patients with pseudolymphomatous folliculitis, 11 with MALT<\/jats:styled-content> lymphoma, and 5 with cutaneous lymphoid hyperplasia (CLH<\/jats:styled-content>). The clinical, histopathologic and immunohistochemical characteristics were reviewed and three major characteristics assessed: (a) proportion of T cells expressing PD<\/jats:styled-content>\u20101, (b) pattern of expression of CD1a<\/jats:styled-content> by dendritic cells and (c) pattern of expression of S100<\/jats:styled-content> by dendritic cells.<\/jats:p><\/jats:sec>Results<\/jats:title>We found pseudolymphomatous folliculitis to have a significant increase in PD<\/jats:styled-content>\u20101+ T cells compared with MALT<\/jats:styled-content> lymphoma (p < 0.0001). The pattern of CD1a<\/jats:styled-content> staining is also informative: MALT<\/jats:styled-content> lymphoma is significantly more likely to demonstrate a peripheral concentration of CD1a<\/jats:styled-content>+ dendritic cells around lymphoid nodules than pseudolymphomatous folliculitis (p < 0.0003) or CLH<\/jats:styled-content> (p < 0.05). Pseudolymphomatous folliculitis demonstrates an interstitial distribution of CD1a<\/jats:styled-content>+ cells more often than MALT<\/jats:styled-content> lymphoma (p < 0.04). S100<\/jats:styled-content> staining was not a helpful discriminator.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Histopathologic factors including PD<\/jats:styled-content>\u20101 and CD1a<\/jats:styled-content> staining patterns may allow for more certainty in distinguishing lymphoid hyperplasia, including pseudolymphomatous folliculitis, from MALT<\/jats:styled-content> lymphoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12440","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T08:59:15Z","timestamp":1415696355000},"page":"6-15","source":"Crossref","is-referenced-by-count":28,"title":["PD<\/scp>\u20101, S\u2010100 and CD1a<\/scp> expression in pseudolymphomatous folliculitis, primary cutaneous marginal zone B\u2010cell lymphoma (MALT<\/scp> lymphoma) and cutaneous lymphoid hyperplasia"],"prefix":"10.1111","volume":"42","author":[{"given":"Amrita","family":"Goyal","sequence":"first","affiliation":[{"name":"Dermatopathology Unit Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna B.","family":"Moore","sequence":"additional","affiliation":[{"name":"Dermatopathology Unit Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon","family":"Gimbel","sequence":"additional","affiliation":[{"name":"Dermatopathology Unit Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joi B.","family":"Carter","sequence":"additional","affiliation":[{"name":"Dermatopathology Unit Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Kroshinsky","sequence":"additional","affiliation":[{"name":"Dermatopathology Unit Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Ferry","sequence":"additional","affiliation":[{"name":"Dermatopathology Unit Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Harris","sequence":"additional","affiliation":[{"name":"Dermatopathology Unit Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyn M.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Dermatopathology Unit Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.02.012"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199911000-00001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1001\/archderm.1988.01670080087027","article-title":"A solitary nodule of the left cheek","volume":"124","author":"Kibbi A","year":"1988","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31817bdcfb"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051843"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341194"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.10.010"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2005.tb00805.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199901000-00010"},{"key":"e_1_2_5_11_1","first-page":"262","article-title":"Pseudolymphomatous folliculitis presenting with multiple nodules","volume":"19","author":"Nakamura M","year":"2009","journal-title":"Eur J Dermatology"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181d8e375"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.113937"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70154-9"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336207"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04961.x"},{"key":"e_1_2_5_17_1","first-page":"214","volume-title":"WHO classification of tumors of haematopoietic and lymphoid tissues","author":"Isaacson P","year":"2008"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(03)00075-3"},{"key":"e_1_2_5_19_1","unstructured":"NCCN. 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