{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:55:50Z","timestamp":1780667750510,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T00:00:00Z","timestamp":1423094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Background<\/jats:title>Podoconiosis is a familial geochemical dermatosis which is common in Ethiopia but relatively unknown in Europe\/United States. It is related to exposure of bare feet to volcanic soil and presents with extensive bilateral lymphedema of legs and feet. Histopathological and immunohistochemical features of it have not been described yet.<\/jats:p><\/jats:sec>Objectives<\/jats:title>The objectives of this study are to characterize podoconiosis histopathologically and immunohistochemically and to increase awareness of the disease.<\/jats:p><\/jats:sec>Methods<\/jats:title>Ten specimens of fully developed podoconiosis were examined with hematoxylin\/eosin, periodic acid\u2010Schiff, Gram, elastica\u2010van Gieson stainings, with immunohistochemistry (CD3<\/jats:styled-content>,CD20<\/jats:styled-content>,CD31<\/jats:styled-content>,CD68<\/jats:styled-content>,CD138<\/jats:styled-content>, tryptase, podoplanin, collagen IV<\/jats:styled-content>), and with polymerase chain reaction (PCR) for human papillomavirus (HPV<\/jats:styled-content>)\u2010specific DNA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>All specimens showed verrucous acanthosis and papillomatosis. Eccrine ducts demonstrated hyperplasia, syringofibroadenomatous changes and miliaria. Dermal collagen bundles were thickened, and elastic fibers were dramatically reduced. A moderate lymphoplasmacytic infiltrate was joined by mast cells and scattered macrophages; neutrophils and eosinophils were sparse. Blood vessels were increased, dilated, and often sclerotic while lymphatics were reduced and largely not dilated. HPV\u2010PCR<\/jats:styled-content> was negative in all specimens.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Podoconiosis demonstrates distinctive changes of chronic lymphedema with extensive sclerosis, loss of elastic fibers, verrucous acanthosis (not HPV<\/jats:styled-content> induced) and reactive changes of eccrine structures. Mast cells, macrophages and altered blood vessels may be involved in the pathogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12441","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T15:05:33Z","timestamp":1416236733000},"page":"173-181","source":"Crossref","is-referenced-by-count":15,"title":["Histopathological and immunohistochemical features of nodular podoconiosis"],"prefix":"10.1111","volume":"42","author":[{"given":"Wendemagegn","family":"Enbiale","sequence":"first","affiliation":[{"name":"Federal Ministry of Health Ethiopia, Addis Abeba Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajalakshmi","family":"Tirumalae","sequence":"additional","affiliation":[{"name":"St. John's Medical College Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almut","family":"B\u00f6er\u2010Auer","sequence":"additional","affiliation":[{"name":"Dermatologikum Hamburg Hamburg 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