{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:16:01Z","timestamp":1766268961250},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>Primary cutaneous <jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content>\u2010positive small\/medium pleomorphic T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">SMPTCL<\/jats:styled-content>) is an indolent form of cutaneous lymphoma that usually presents in solitary fashion and is histopathologically characterized by nodular infiltration of small\u2010 to medium\u2010sized pleomorphic T\u2010cells. We report the case of a patient who presented with a 5\u2010year history of acneiform lesions on his face. Histopathologic examination of two lesions revealed a nodular infiltrate of small to medium\u2010sized lymphocytes with necrosis in the dermis. The proliferating cells were positive for <jats:styled-content style=\"fixed-case\">CD2<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD3<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content> and negative for <jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD30<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CD56<\/jats:styled-content>. They were positive for <jats:styled-content style=\"fixed-case\">TIA<\/jats:styled-content>\u20101 and negative for perforin and granzyme B. The Ki67 proliferation index was approximately 10%. The neoplastic cells expressed programmed death\u20101 and lacked expression of <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\u201013, bcl\u20106 and <jats:styled-content style=\"fixed-case\">CD10<\/jats:styled-content>. <jats:italic>In situ<\/jats:italic> hybridization for Epstein\u2013Barr virus\u2010encoded <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> yielded a negative result. T\u2010cell receptor gene rearrangement showed identical T\u2010lymphocyte monoclonality in both lesions. In brief, we report a rare case of acneiform <jats:styled-content style=\"fixed-case\">SMPTCL<\/jats:styled-content> with prominent necrosis.<\/jats:p>","DOI":"10.1111\/cup.12443","type":"journal-article","created":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T09:23:03Z","timestamp":1416388983000},"page":"265-270","source":"Crossref","is-referenced-by-count":5,"title":["Acneiform primary cutaneous <scp>CD4<\/scp>\u2010positive small\/medium pleomorphic T\u2010cell lymphoma with prominent necrosis"],"prefix":"10.1111","volume":"42","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Xijing Hospital, Fourth Military Medical University  Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital, Fourth Military Medical University  Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianwen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital, Fourth Military Medical University  Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_6_3_1","first-page":"302","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Gaulard P","year":"2008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690210039007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31819f19bb"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.1307"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.07.028"},{"key":"e_1_2_6_8_1","article-title":"CD4+ primary cutaneous small\/medium\u2010sized pleomorphic T\u2010cell lymphoma: a retrospective case series and review of literature","author":"James E","year":"2014","journal-title":"Leuk Lymphoma"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318068b527"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01278.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31818e52fe"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318230df87"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12234"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70304-K"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.10.036"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.07.035"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12028"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/archderm.1996.03890300111015","article-title":"Pilotropic cutaneous T\u2010cell lymphoma without mucinosis. A variant of mycosis fungoides? 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