{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:24:03Z","timestamp":1766269443474},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T00:00:00Z","timestamp":1419811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>We report a hitherto undescribed unusual <jats:styled-content style=\"fixed-case\">CD30<\/jats:styled-content>+ clonal T\u2010cell proliferation in a 46\u2010year\u2010old man with the lymphocytic variant of hypereosinophilic syndrome with a 17\u2010year history of pruritus, generalized persistent papulonodular skin lesions and peripheral blood hypereosinophilia. A skin biopsy showed an eosinophil\u2010rich infiltrate with small to medium\u2010sized <jats:styled-content style=\"fixed-case\">CD30<\/jats:styled-content>+ lymphocytes and Churg\u2010Strauss granulomas. Peripheral blood flow cytometry revealed an aberrant T\u2010cell clone which, molecular genetically, was identical to the T\u2010cell clone detected in the skin. No genetic aberrations of platelet\u2010derived growth factor receptor alpha (<jats:italic><jats:styled-content style=\"fixed-case\">PDGFRA<\/jats:styled-content><\/jats:italic>), <jats:styled-content style=\"fixed-case\">FIP1L1\u2010PDGFRA<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">PDGFRB<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">FGFR1<\/jats:styled-content> were found. The skin lesions showed transient response to systemic and topical corticosteroids. The skin lesions represent cutaneous involvement by clonal T\u2010cells in hypereosinophilic syndrome and differ from known cutaneous CD30+ lymphoproliferative disorders.<\/jats:p>","DOI":"10.1111\/cup.12454","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T07:47:22Z","timestamp":1416901642000},"page":"130-135","source":"Crossref","is-referenced-by-count":7,"title":["<scp>CD30<\/scp>+ clonal T\u2010cell lymphoid proliferation of the skin in a patient with hypereosinophilic syndrome"],"prefix":"10.1111","volume":"42","author":[{"given":"Werner","family":"Kempf","sequence":"first","affiliation":[{"name":"Kempf und Pfaltz Histologische Diagnostik  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry V.","family":"Kazakov","sequence":"additional","affiliation":[{"name":"Department of Pathology Charles University, Medical Faculty Hospital  Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Szep","sequence":"additional","affiliation":[{"name":"Cytopathos Laboratory  Bratislava Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Vanecek","sequence":"additional","affiliation":[{"name":"Bioptical Laboratory  Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,29]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2007.07.009"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23293"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2007.07.002"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3283366c70"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.11.81"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2012.01.009"},{"key":"e_1_2_4_8_1","first-page":"596","article-title":"The hypereosinophilic syndrome: fluorescence in situ hybridization detects the del(4)(q12)\u2010FIP1L1\/PDGFRA but not genomic rearrangements of other tyrosine kinases","volume":"90","author":"La Starza R","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06637.x"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930902832348"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/1042819031000083073"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00979.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00495.x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982042"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053723"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001115)89:10<2138::AID-CNCR15>3.0.CO;2-W"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07416.x"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03382.x"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2012.725238"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.03.017"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.12.952"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31824f4f66"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182648596"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00778.x"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355479"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12454","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:04:37Z","timestamp":1696363477000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,29]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/cup.12454"],"URL":"https:\/\/doi.org\/10.1111\/cup.12454","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,29]]}}}