{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:51:51Z","timestamp":1778619111074,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T00:00:00Z","timestamp":1423872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"CD8+ cytotoxic T\u2010cell lymphoma involving the skin represents a heterogeneous group of diseases that include subcutaneous panniculitis\u2010like T\u2010cell lymphoma, primary cutaneous aggressive epidermotropic CD8<\/jats:styled-content>+ cytotoxic T\u2010cell lymphoma, and \u2018type D\u2019 lymphomatoid papulosis. In this report, we describe a case of CD8<\/jats:styled-content>+ cytotoxic T\u2010cell lymphoma involving both the epidermis and subcutis. The patient was a 6\u2010year\u2010old girl who presented with a 3\u2010year history of multiple plaques on her trunk and legs. The lesions had relapsed twice but responded well to prednisone. Histopathologic examination showed the proliferation of atypical lymphocytes in the epidermis, dermis and subcutaneous tissue. On immunohistochemical analysis, the atypical lymphocytes were positive for \u03b2F1<\/jats:styled-content>, CD3<\/jats:styled-content>, CD8<\/jats:styled-content>, perforin, granzyme B and TIA<\/jats:styled-content>\u20101, but negative for T\u2010cell receptor (TCR<\/jats:styled-content>) \u03b3, CD4<\/jats:styled-content>, CD30<\/jats:styled-content> and CD56<\/jats:styled-content>. It was difficult to classify this tumor in terms of the known types of cutaneous lymphoma, and this case should be differentiated with subcutaneous panniculitis\u2010like T\u2010cell lymphoma and primary cutaneous aggressive epidermotropic CD8<\/jats:styled-content>+ T\u2010cell lymphoma.<\/jats:p>","DOI":"10.1111\/cup.12458","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T21:53:08Z","timestamp":1417557188000},"page":"271-275","source":"Crossref","is-referenced-by-count":10,"title":["Primary cutaneous CD8+ cytotoxic T\u2010cell lymphoma involving the epidermis and subcutis in a young child"],"prefix":"10.1111","volume":"42","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xijing Hospital The Fourth Military Medical University Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianwen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital The Fourth Military Medical University Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xijing Hospital The Fourth Military Medical University Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00495.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31817a9081"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118492505.ch5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65144-9"},{"key":"e_1_2_5_7_1","article-title":"Aggressive epidermotropic cutaneous CD8+ lymphoma: a cutaneous lymphoma withdistinct clinical and pathological features report of an EORTC cutaneous lymphoma task force workshop","author":"Robson A","year":"2014","journal-title":"Histopathology"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118492505.ch6"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e75356"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000307"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181a84f32"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2011.03369.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000187933.87103.03"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12458","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:25:41Z","timestamp":1696361141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,14]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/cup.12458"],"URL":"https:\/\/doi.org\/10.1111\/cup.12458","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,14]]}}}