{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:31:20Z","timestamp":1785771080562,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>Merkel cell carcinoma (MCC) has been reported in association with other types of cutaneous neoplasms within the same lesion, including squamous cell carcinoma, Bowen's disease, actinic keratosis, follicular cysts, trichoblastoma and lentigo maligna, among others. However, the association of MCC and sweat gland tumors has never been described in the literature. We report two unique cases of MCC that developed within cutaneous poromas. A 56\u2010year\u2010old male (Patient 1) and an 81\u2010year\u2010old female (Patient 2) presented with nodules on the upper arm and lower back, respectively. Histopathologic study of both cases revealed a tumor in the dermis composed of poroid and cuticular cells intermingled with a proliferation of small round cells that showed characteristic histopathological and immunohistochemical features of MCC. In both cases, the two neoplasms were tightly admixed and distinct, suggesting that the MCC could have developed within a previously existing poroma. No morphological features of transition between the two tumors were seen. Neoplastic cells of MCC expressed immunoreactivity for chromogranin, synaptophysin, neuron\u2010specific enolase, CAM 5.2 and cytokeratin 20, the last two markers showing the characteristic paranuclear dot\u2010like pattern. In contrast, the poroma cells only expressed cytokeratin MNF116. Metastatic deposits were not identified in the regional lymph nodes or distantly.<\/jats:p>","DOI":"10.1111\/cup.12468","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T07:45:47Z","timestamp":1425368747000},"page":"353-360","source":"Crossref","is-referenced-by-count":13,"title":["Merkel cell carcinoma arising within a poroma: report of two cases"],"prefix":"10.1111","volume":"42","author":[{"given":"Ana M.","family":"Molina\u2010Ruiz","sequence":"first","affiliation":[{"name":"Department of Dermatology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz Universidad Aut\u00f3noma Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7342-1856","authenticated-orcid":false,"given":"Claudia","family":"Bern\u00e1rdez","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz Universidad Aut\u00f3noma Madrid 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