{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:22:50Z","timestamp":1790947370011,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Background<\/jats:title>Primary cutaneous cribriform carcinoma (PCCC<\/jats:styled-content>) is a rare and under\u2010recognized variant of sweat gland carcinoma, characterized by anastomosing tubules and solid nests producing a sieve\u2010like appearance.<\/jats:p><\/jats:sec>Methods<\/jats:title>Six cases of PCCC<\/jats:styled-content> were clinically, histopathologically and immunophenotypically studied.<\/jats:p><\/jats:sec>Results<\/jats:title>All cases showed an unencapsulated, nodular dermal tumor composed of solid and cribriform nests, cords and tubules embedded within a desmoplastic stroma. Some tubules showed micropapillary projections reminiscent of tubular adenoma, and intraluminal thin bridges resembling adenomatoid tumor. One case showed a predominantly solid component. Only two cases showed very focal decapitation secretion. Tumor cells expressed CK7<\/jats:styled-content>, CK5<\/jats:styled-content>\/6, EMA<\/jats:styled-content>, CEA<\/jats:styled-content>, S\u2010100, BerEP4<\/jats:styled-content> and c\u2010kit and were negative for cytokeratin 20, estrogen receptor\/progesterone receptor (ER<\/jats:styled-content>\/PR<\/jats:styled-content>), androgen receptor and GCDFP<\/jats:styled-content>\u201015. Calponin, p63 and smooth muscle actin (SMA<\/jats:styled-content>) showed absence of a myoepithelial layer.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Contrary to the original reports, our series shows that PCCC<\/jats:styled-content> may be predominantly solid with only a minor cribriform component, and expresses c\u2010kit and S\u2010100 which may potentially lead to the misdiagnosis of adenoid cystic carcinoma. Immunohistochemical stains may aid in distinction from tubular adenoma. Current data suggest a favorable outcome, as metastatic disease has not been reported to date.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12469","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T07:45:10Z","timestamp":1425368710000},"page":"379-387","source":"Crossref","is-referenced-by-count":43,"title":["Primary cutaneous cribriform carcinoma: report of six cases with clinicopathologic data and immunohistochemical profile"],"prefix":"10.1111","volume":"42","author":[{"given":"David P.","family":"Arps","sequence":"first","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May P.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA,"},{"name":"Department of Dermatology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA,"},{"name":"Department of Dermatology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleodor A.","family":"Andea","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA,"},{"name":"Department of Dermatology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,26]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Neoplasms with apocrine differentiation","author":"Requena L","year":"1998"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00375.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-007-0377-4"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.032"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318299fcac"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29196.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591577506801021"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199812000-00005"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70454-8"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1258\/0022215011908595"},{"key":"e_1_2_5_12_1","volume-title":"Cutaneous adnexal tumors","author":"Kazakov DV","year":"2012"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181839aad"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200208000-00013"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-200107000-00012"},{"key":"e_1_2_5_16_1","first-page":"576","article-title":"Adenocarcinoma in situ arising in a tubulopapillary apocrine hidradenoma of the peri\u2010anal region","volume":"16","author":"Obaidat NA","year":"2006","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_17_1","first-page":"927","article-title":"Apocrine adenocarcinoma of the bilateral axillae","volume":"41","author":"Yoshida A","year":"1991","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181590ba4"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/109.1.75"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.019794"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000096046.42833.C7"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198602000-00002"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.06.065"},{"key":"e_1_2_5_24_1","volume-title":"World Health Organization classification of tumours. 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