{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:46:41Z","timestamp":1778755601861,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T00:00:00Z","timestamp":1428969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"The presence of Melan\u2010A positive dermal cells in excisions for melanoma in situ<\/jats:italic> represents a frequent conundrum for pathologists. These cells may represent superficially invasive melanoma, benign, incidental, dermal nevi or non\u2010specific staining of dermal melanophages. Occasionally, rare, Melan\u2010A positive dermal cells are present which do not clearly correspond to the above three categories. Our objective was to further characterize these Melan\u2010A positive dermal cells. To do this, immunoperoxidase staining for Melan\u2010A and SOX\u201010 was performed on 188\u2010cutaneous excisions, including examples of melanoma in situ<\/jats:italic>, atypical junctional melanocytic hyperplasia and non\u2010melanocytic tumors. These were evaluated for the presence of Melan\u2010A and SOX\u201010 positive dermal cells. Dermal cells, positive for both markers, were identified in 17% of the excisions. The cells were present in 10% of cases from the melanocytic group and 31% of the cases from the non\u2010melanocytic group. These cells did not exhibit cytologic atypia and resembled neither the co\u2010existing neoplasm nor melanophages. We conclude that positivity of these rare Melan\u2010A positive cells for SOX\u201010<\/jats:styled-content> argues that they represent true melanocytes and not non\u2010specific staining. The absence of cytologic atypia in these cells and their presence in excisions of non\u2010melanocytic neoplasms argues that they are benign, reactive, dermal melanocytes.<\/jats:p>","DOI":"10.1111\/cup.12473","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T09:49:06Z","timestamp":1425289746000},"page":"388-393","source":"Crossref","is-referenced-by-count":26,"title":["Melan\u2010A positive dermal cells in malignant melanoma in situ<\/i>"],"prefix":"10.1111","volume":"42","author":[{"given":"Mary Elizabeth","family":"Danga","sequence":"first","affiliation":[{"name":"Section of Dermatopathology, Department of Dermatology Boston University School of Medicine Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Yaar","sequence":"additional","affiliation":[{"name":"Aurora Diagnostics GPA Laboratories Greensboro NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jag","family":"Bhawan","sequence":"additional","affiliation":[{"name":"Section of Dermatopathology, Department of Dermatology Boston University School of Medicine Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3182a3877a"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2002.290703.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31815f9854"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02385.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000175532.27368.3f"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00855.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02482-4"},{"issue":"2","key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0190-9622(97)80386-6","article-title":"Eruptive melanocytic nevi after Stevens\u2010Johnson syndrome","volume":"37","author":"Shoji T","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_5_10_1","first-page":"247","article-title":"Proliferation and malignant transformation of melanocytes","volume":"2","author":"Halaban R","year":"1991","journal-title":"Crit Rev Oncog"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.12.035"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01568.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200304000-00013"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01442.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000072"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12279"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.115"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12473","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:23:18Z","timestamp":1696306998000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,14]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/cup.12473"],"URL":"https:\/\/doi.org\/10.1111\/cup.12473","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,14]]}}}