{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:09:08Z","timestamp":1790287748158,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>Neoplasms originating from nail matrix keratinocytes are very rare. Onychomatricoma and onychocytic matricoma are benign tumors arising from nail matrix keratinocytes. Only one case of onychocytic carcinoma, the malignant counterpart of onychocytic matricoma, has been reported in the literature. Herein, we describe a case of invasive onychocytic carcinoma. Two biopsy specimens of the tumor, obtained at early and invasive stages, were examined histopathologically. The first biopsy specimen showed a retiform proliferation of eosinophilic and basophilic cells in the nail matrix. The second biopsy specimen showed a retiform basophilic cell proliferation with focal keratinization. Similar to normal nail matrix keratinocytes, the proliferating basophilic cells failed to express cytokeratin (<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>)1, <jats:styled-content style=\"fixed-case\">CK6<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CK10<\/jats:styled-content>. Focal expression of hair\u2010specific keratins, including <jats:styled-content style=\"fixed-case\">K31<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">K85<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">K86<\/jats:styled-content>, was observed. On the basis of these findings, the tumor was identified as an invasive malignant tumor originating from nail matrix keratinocytes.<\/jats:p>","DOI":"10.1111\/cup.12476","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T10:10:57Z","timestamp":1425291057000},"page":"361-367","source":"Crossref","is-referenced-by-count":4,"title":["Invasive onychocytic carcinoma"],"prefix":"10.1111","volume":"42","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Xijing Hospital, Fourth Military Medical University  Xian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital, Fourth Military Medical University  Xian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital, Fourth Military Medical University  Xian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb11827.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.03.029"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70004-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200206000-00002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.040"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181af8516"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181f8c39a"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12373"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31822c3d8b"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12122"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.6358"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3182827fec"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03246.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.12.027"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31826b74b8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01173.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e318293f387"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200410000-00010"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.07.015"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12476","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:57:17Z","timestamp":1696355837000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,6]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/cup.12476"],"URL":"https:\/\/doi.org\/10.1111\/cup.12476","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,6]]}}}