{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:47:51Z","timestamp":1696405671064},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>Dermal melanophages are frequently encountered in both benign melanocytic nevi and malignant melanoma. In contrast, intraepidermal melanophages (<jats:styled-content style=\"fixed-case\">IEM<\/jats:styled-content>) are under\u2010recognized in melanocytic lesions and their biologic significance is not understood. Herein, we report the clinical and histopathologic features of five melanocytic lesions featuring <jats:styled-content style=\"fixed-case\">IEM<\/jats:styled-content> encountered prospectively in our dermatopathology practice at the University of Chicago. Two hundred and  thirty\u2010one (231) archived skin primary melanocytic proliferations were also investigated retrospectively in a de\u2010identified, archival teaching set collection. Nineteen of 231 of the archived cases were positive for <jats:styled-content style=\"fixed-case\">IEM<\/jats:styled-content>. Among the total 24 <jats:styled-content style=\"fixed-case\">IEM<\/jats:styled-content>\u2010positive cases (5 prospective and 19 archived cases), 13 were categorized as Spitz nevi (p\u2009&lt;\u20090.0001) and 3 as atypical Spitz tumors (p\u2009=\u20090.0152). Fourteen of 24 cases with <jats:styled-content style=\"fixed-case\">IEM<\/jats:styled-content> also exhibited intracorneal melanocytes (p\u2009&lt;\u20090.0001). <jats:styled-content style=\"fixed-case\">IEM<\/jats:styled-content> are evidently not rare, especially in spitzoid melanocytic neoplasms. <jats:styled-content style=\"fixed-case\">IEM<\/jats:styled-content> in our series were significantly correlated with intracorneal melanocytosis, possibly indicating an association between <jats:styled-content style=\"fixed-case\">IEM<\/jats:styled-content> and suprabasal melanocytosis and\/or transepidermal elimination of melanocytes.<\/jats:p>","DOI":"10.1111\/cup.12479","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T07:44:46Z","timestamp":1425368686000},"page":"394-399","source":"Crossref","is-referenced-by-count":2,"title":["Melanocytic tumors with intraepidermal melanophages: a report of five cases with review of 231 archived cutaneous melanocytic tumors"],"prefix":"10.1111","volume":"42","author":[{"given":"Masakazu","family":"Fujimoto","sequence":"first","affiliation":[{"name":"Department of Medicine, Section of Dermatology The University of Chicago Medicine  Chicago IL USA"},{"name":"Department of Diagnostic Pathology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana L.","family":"Basko\u2010Plluska","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Dermatology The University of Chicago Medicine  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Krausz","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Chicago Medicine  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Angelica","family":"Selim","sequence":"additional","affiliation":[{"name":"Department of Pathology Duke University Medical Center  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R.","family":"Shea","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Dermatology The University of Chicago Medicine  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1027"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.014"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.01.009"},{"key":"e_1_2_5_6_1","first-page":"3330","article-title":"Tumor\u2010associated macrophages promote angiogenesis and melanoma growth via adrenomedullin in a paracrine and autocrine manner","volume":"27","author":"Chen P","year":"2009","journal-title":"J Clin 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