{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:55:46Z","timestamp":1782888946601,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T00:00:00Z","timestamp":1428451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous infection with the mite <jats:italic>Sarcoptes scabiei var. hominis<\/jats:italic> is associated with epidermal and dermal changes. After noting superficial fibrin thrombi in two biopsies with scabies mites, we comprehensively reviewed the histopathologic findings in scabietic infections to determine the frequency of this finding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty five biopsies of scabies infection were retrieved from the archives of our institution; only cases containing scabietic mite parts or scybala were included. The microscopic features were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nearly half (40%) of the cases showed fibrin thrombi within vessels of the superficial dermis. Other frequent findings included dermal eosinophils (88% of cases), epidermal spongiosis (76% of cases), lymphocyte atypia (64%), a superficial and deep infiltrate (52% of cases), dermal neutrophils (52%) and endothelial cell swelling (52%). Half of the cases contained polarizable mite elements. Less commonly encountered features included extravasated erythrocytes (44%), dermal edema (32%), pink \u2018pigtails\u2019(28%), intraepidermal pustules (24%), plasma cells (20%) and vasculitis (4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The pathologic characteristics of scabietic infection are wide\u2010ranging. Spongiosis, superficial and deep inflammation, and dermal eosinophils and neutrophils are seen in the majority of cases. Superficial fibrin thrombi are not uncommon in scabietic infection, and may provide a helpful diagnostic clue when mites are not visible on initial sections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12482","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T09:52:39Z","timestamp":1425549159000},"page":"346-352","source":"Crossref","is-referenced-by-count":25,"title":["Superficial fibrin thrombi \u2026 and other findings: a review of the histopathology of human scabietic infections"],"prefix":"10.1111","volume":"42","author":[{"given":"Hillary","family":"Elwood","sequence":"first","affiliation":[{"name":"Department of Pathology University of New Mexico School of Medicine  Albuquerque NM 87125 USA"},{"name":"Department of Dermatology University of New Mexico School of Medicine  Albuquerque NM 87125 USA"},{"name":"Pathology Associates of Albuquerque  Albuquerque NM 87125 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan 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