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Within the TFI component of the nevus sebaceus, there was intracytoplasmic accumulation of eosinophilic keratin, as shown on pancytokeratin\u2010stained sections, imparting a signet\u2010ring appearance to the cells. To our knowledge, this is the first report of signet\u2010ring cells arising within a TFI occurring in a nevus sebaceus. We discuss this case as well as review the literature on multiple tumors arising within nevus sebaceus and signet\u2010ring cell changes in primary cutaneous tumors.<\/jats:p>","DOI":"10.1111\/cup.12489","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T05:48:20Z","timestamp":1426139300000},"page":"645-651","source":"Crossref","is-referenced-by-count":17,"title":["Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum with signet\u2010ring cells, all arising in nevus sebaceus"],"prefix":"10.1111","volume":"42","author":[{"given":"Emilie","family":"Dore","sequence":"first","affiliation":[{"name":"Carver College of Medicine University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan H.","family":"Noe","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Iowa  Iowa City IA 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