{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:21:42Z","timestamp":1778498502367,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Endocrine mucin\u2010producing sweat gland carcinoma is a cutaneous adnexal tumor that is rarely reported in the literature. We identified only 29 previously reported cases. All these cases share some clinical morphologic and immunohistochemical features. Among the immunohistochemical markers, cytokeratins 5\/6, 8 and 18 (<jats:styled-content style=\"fixed-case\">CK5<\/jats:styled-content>\/6, <jats:styled-content style=\"fixed-case\">CK8<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CK18<\/jats:styled-content>) had not been previously studied in this tumor. Although studies with cytokeratin Cam5.2 exist, we know at present that this marker does not correspond to antibodies <jats:styled-content style=\"fixed-case\">CK8<\/jats:styled-content>\/18, but rather to <jats:styled-content style=\"fixed-case\">CK7<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CK8<\/jats:styled-content>. We studied three examples of endocrine mucin\u2010producing sweat gland carcinoma with 18 immunostains. Our cases showed an immunoprofile <jats:styled-content style=\"fixed-case\">CK8<\/jats:styled-content>+, <jats:styled-content style=\"fixed-case\">CK18<\/jats:styled-content>+, <jats:styled-content style=\"fixed-case\">CK5<\/jats:styled-content>\/6\u2212 (or only focally positive), <jats:styled-content style=\"fixed-case\">CK7<\/jats:styled-content>+, <jats:styled-content style=\"fixed-case\">GCDFP<\/jats:styled-content>\u201015+ (2 cases), estrogen receptor+, progesterone receptor+, <jats:styled-content style=\"fixed-case\">HER2<\/jats:styled-content>\u2010, neuron\u2010specific enolase\u2009+\u2009(2 cases), anti\u2010synaptophysin+, chromogranin A +, <jats:styled-content style=\"fixed-case\">CD56<\/jats:styled-content> variable (1 case +, 1 case\u2212), <jats:styled-content style=\"fixed-case\">CD57<\/jats:styled-content>\u2010, anti\u2010human <jats:styled-content style=\"fixed-case\">D2<\/jats:styled-content>\u201040\u2010 (two cases), p63\u2010 or focally positive, smooth muscle actin\u2009+\u2009with variable pattern of expression and smooth muscle myosin heavy chain expressed in a peripheral discontinuous layer in some nodules, but absent in most.<\/jats:p>","DOI":"10.1111\/cup.12512","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T06:39:25Z","timestamp":1430375965000},"page":"578-586","source":"Crossref","is-referenced-by-count":26,"title":["Endocrine mucin\u2010producing sweat gland carcinoma: a study of three cases and <scp>CK8<\/scp>, <scp>CK18<\/scp> and <scp>CD5<\/scp>\/6 immunoexpression"],"prefix":"10.1111","volume":"42","author":[{"given":"Angel","family":"Fernandez\u2010Flores","sequence":"first","affiliation":[{"name":"Department of Cellular Pathology Hospital El Bierzo  Ponferrada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Cassarino","sequence":"additional","affiliation":[{"name":"Department of Pathology, Southern California Kaiser Permanente Los Angeles 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