{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:16:44Z","timestamp":1766269004416},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T00:00:00Z","timestamp":1435881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The histopathologic diagnosis of mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>) has classically relied on the presence of atypical epidermotropic T\u2010lymphocytes predominating over spongiosis. However, in some cases of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>, prominent epidermal mucinosis in a spongiosis\u2010like pattern mimics a spongiotic dermatitis. To our knowledge, only one series in the literature has thus far recognized the presence of epidermal mucinosis in <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated 30 skin biopsies from 18 patients with the clinical diagnosis of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>, which fulfilled all histopathologic criteria for patch\u2010 or plaque\u2010stage <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>, but also showed epidermal mucinosis in a spongiosis\u2010like pattern. A total of 15 specimens were studied by immunohistochemistry, and seven were tested for T\u2010cell receptor (<jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>) gene rearrangements. Twenty biopsies of spongiotic dermatitides were included as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We confirmed the presence of epidermal mucinosis in all 30 cases of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> with a spongiosis\u2010like pattern based on histopathologic criteria and the colloidal iron stain for mucin. Immunohistochemistry in 15 specimens showed significant loss of pan\u2010T\u2010cell antigens <jats:styled-content style=\"fixed-case\">CD5<\/jats:styled-content> (10\/15) and <jats:styled-content style=\"fixed-case\">CD7<\/jats:styled-content> (14\/15); and <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> clonality was detected in 7 specimens from 6 patients, supporting the diagnosis of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report helpful histopathologic criteria for distinguishing <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> with epidermal mucinosis in a spongiosis\u2010like pattern from spongiotic dermatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12513","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T07:17:14Z","timestamp":1432624634000},"page":"730-738","source":"Crossref","is-referenced-by-count":10,"title":["Mycosis fungoides with epidermal mucinosis: a variant of mycosis fungoides with a spongiosis\u2010like pattern"],"prefix":"10.1111","volume":"42","author":[{"given":"Stephanie W.","family":"Hu","sequence":"first","affiliation":[{"name":"Dermatopathology Section, Ronald O. Perelman Department of Dermatology New York University School of Medicine  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Ratech","sequence":"additional","affiliation":[{"name":"Department of Pathology, Montefiore Medical Center Albert Einstein College of Medicine  Bronx NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizwan","family":"Naeem","sequence":"additional","affiliation":[{"name":"Department of Pathology, Montefiore Medical Center Albert Einstein College of Medicine  Bronx NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u2010Ann","family":"Latkowski","sequence":"additional","affiliation":[{"name":"Ronald O. Perelman Department of Dermatology New York University School of Medicine  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideko","family":"Kamino","sequence":"additional","affiliation":[{"name":"Dermatopathology Section, Ronald O. 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