{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:33:50Z","timestamp":1772508830825,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intravascular lymphoma is a rare type of lymphoma that frequently affects the skin and is usually of B\u2010cell origin. This lymphoma type is very rare and not recognized as a separate entity in the 2008 World Health Organization classification of hematopoietic and lymphoid tissue tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reported five cases of intravascular <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\/T cell lymphoma with cutaneous manifestation and reviewed 12 published cases involving Chinese patients with similar characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All five patients were adults who exhibited red or brown patches or plaques on the lower extremities or trunk; four cases were associated with B symptoms; one case developed subsequent to a lymphoma on the face (possibly extranodal <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\/T cell lymphoma, nasal type). Histopathologically, all patients exhibited abnormal, medium\u2010sized intravascular lymphocytes in the dermis and subcutaneous tissues. All patients were positive for <jats:styled-content style=\"fixed-case\">CD2<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD3\u03f5<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD56<\/jats:styled-content> and cytotoxic proteins. All cases were Epstein\u2010Barr virus (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>) positive. Four of FIVE patients died of lymphoma within a few months of diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravascular <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\/T\u2010cell lymphoma is a rare highly aggressive and <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010associated lymphoma that is prone to develop in Chinese patients. The relationship between intravascular <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\/T\u2010cell lymphoma and extranodal <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\/T\u2010cell lymphoma, nasal type, requires clarification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12515","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T10:26:01Z","timestamp":1430389561000},"page":"610-617","source":"Crossref","is-referenced-by-count":18,"title":["Intravascular <scp>NK<\/scp>\/T\u2010cell lymphoma: a report of five cases with cutaneous manifestation from China"],"prefix":"10.1111","volume":"42","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xijing Hospital The Fourth Military Medical University  Xian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Third Affiliated Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shandong Jining No. 1 People's Hospital  Jining China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changzheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Third 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